Clinical evaluation of silicone gel in the treatment of cleft lip scars

Chun Shin Chang, Christopher Glenn Wallace, Yen Chang Hsiao, Jung Ju Huang, Zung Chung Chen, Chee Jen Chang, Lun Jou Lo, Philip Kuo Ting Chen, Jyh Ping Chen, Yu Ray Chen

Research output: Contribution to journalArticle

Abstract

Upper lip scars are at risk of hypertrophy. Our center therefore uses microporous tape and silicone sheeting for postoperative scar care following cleft lip repair. However, some babies have previously ingested their silicone sheeting, which has the potential for respiratory compromise or gastrointestinal obstruction. Self-dry silicone gel is reportedly also effective for preventing hypertrophic scars. Hence, we sought to test whether silicone gel, which cannot be ingested whole, might be non-inferior to silicone sheeting for controlling against upper lip scar hypertrophy. This was a mixed prospective and retrospective case-controlled clinical trial involving patients undergoing unilateral cleft lip repair, 29 of whom received standard postoperative silicone sheeting (control group) and another 33 age-matched consecutive patients who received self-dry silicone instead. The Vancouver scar scale, visual analogue scale and photographically assessed scar width assessments were the same in both groups at six months after surgery. In conclusion, silicone gel appears to be non-inferior to silicone sheeting for postoperative care of upper lip scars as judged by scar quality at six months, but silicone sheeting has the safety disadvantage that it can be swallowed whole by babies. It is thus recommended that silicone gel be used for upper lip scar management in babies.

Original languageEnglish
Article number7422
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

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Silicone Gels
Cleft Lip
Silicones
Cicatrix
Lip
Postoperative Care
Therapeutics
Hypertrophy
Hypertrophic Cicatrix
Controlled Clinical Trials
Visual Analog Scale
Safety
Control Groups

ASJC Scopus subject areas

  • General

Cite this

Chang, C. S., Wallace, C. G., Hsiao, Y. C., Huang, J. J., Chen, Z. C., Chang, C. J., ... Chen, Y. R. (2018). Clinical evaluation of silicone gel in the treatment of cleft lip scars. Scientific Reports, 8(1), [7422]. https://doi.org/10.1038/s41598-018-25697-x

Clinical evaluation of silicone gel in the treatment of cleft lip scars. / Chang, Chun Shin; Wallace, Christopher Glenn; Hsiao, Yen Chang; Huang, Jung Ju; Chen, Zung Chung; Chang, Chee Jen; Lo, Lun Jou; Chen, Philip Kuo Ting; Chen, Jyh Ping; Chen, Yu Ray.

In: Scientific Reports, Vol. 8, No. 1, 7422, 01.12.2018.

Research output: Contribution to journalArticle

Chang, CS, Wallace, CG, Hsiao, YC, Huang, JJ, Chen, ZC, Chang, CJ, Lo, LJ, Chen, PKT, Chen, JP & Chen, YR 2018, 'Clinical evaluation of silicone gel in the treatment of cleft lip scars', Scientific Reports, vol. 8, no. 1, 7422. https://doi.org/10.1038/s41598-018-25697-x
Chang CS, Wallace CG, Hsiao YC, Huang JJ, Chen ZC, Chang CJ et al. Clinical evaluation of silicone gel in the treatment of cleft lip scars. Scientific Reports. 2018 Dec 1;8(1). 7422. https://doi.org/10.1038/s41598-018-25697-x
Chang, Chun Shin ; Wallace, Christopher Glenn ; Hsiao, Yen Chang ; Huang, Jung Ju ; Chen, Zung Chung ; Chang, Chee Jen ; Lo, Lun Jou ; Chen, Philip Kuo Ting ; Chen, Jyh Ping ; Chen, Yu Ray. / Clinical evaluation of silicone gel in the treatment of cleft lip scars. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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