Clinical efficacy of polycaprolactone β-calcium triphosphate composite for osteoconduction in rabbit bone defect model

Chiu Ming Chen, Shen Mao Chen, Shiou Fu Lin, Huang Chien Liang, Chia Chun Wu

Research output: Contribution to journalArticlepeer-review

Abstract

The combination of β-tricalcium phosphate (β-TCP) with polycaprolactone (PCL) has been considered a promising strategy for designing scaffolds for bone grafting. This study incorporated PCL with commercially available β-TCP (Osteocera™) to fabricate an injectable bone substitute and evaluate the effect of PCL on compressive strength and setting time of the hydraulic cement. The mechanical testing was compliant with the ASTM D695 and ASTM C191-13 standards. Results showed that PCL-TCP composite presented a well-defined architecture with uniform pore distribution and a significant increase in compressive strength compared with β-TCP alone. Eighteen rabbits, each with two surgically created bone defects, were treated using the PCL-TCP composites. The composite materials were resorbed and replaced by newly formed bone tissue. Both PCL-TCP and β-TCP demonstrated equivalent clinical effects on osteoconduction property in terms of the percentage of newly formed bone area measured by histomorphometric analysis. PCL-TCP was proven to be as effective as the commercially available β-TCP scaffold (Osteocera™).

Original languageEnglish
Article number2552
JournalPolymers
Volume13
Issue number15
DOIs
Publication statusPublished - Aug 2021

Keywords

  • -tricalcium phosphate
  • Biocomposites
  • Osteoconduction
  • Polycaprolactone

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

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