Clinical distinction and evaluation of leptospirosis in Taiwan - A case-control study

Huang Yu Yang, Po Yaur Hsu, Ming Jeng Pan, Mai Szu Wu, Chih Hsiung Lee, Chun Chen Yu, Chen Chieh Hung, Chih Wei Yang

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Leptospirosis is the most widespread zoonosis. Leptospirosis remains underreported in Taiwan because of ignorance and the broad spectrum of clinical manifestations. Acute renal failure (ARF) is a prominent feature of leptospirosis. This investigation conducted a case-control study to obtain information to distinguish leptospirosis from other conditions with similar presentations. Methods: Leptospirosis surveillance was performed at Chang Gung Memorial Hospital, Taiwan, between September 2000 and December 2001. Suspected clinical cases were included in the sample and investigated. Diagnosis was confirmed with four-fold or greater increase of microscopic agglutination test (MAT) titer in paired sera; positive immunoglobulin M (IgM) dipstick with single MAT≥400; or isolation of leptospira. Cases were classified as excluded based on confirmed etiology other than leptospirosis or negative paired serologic test. Results: Twenty-two confirmed cases and 21 excluded cases of leptospirosis were identified from among 169 suspected cases. An outbreak was observed during the flooding from Typhoon Nali. L. shermani, the most common serovar in Taiwan, was identified in 78.5% of confirmed cases. In the confirmed group, mean age was 44 ± 14.5 (21-66) yrs similar to that of the excluded group, with male predominance (86.4 vs. 57. 1%, p

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalJournal of Nephrology
Volume18
Issue number1
Publication statusPublished - Jan 2005
Externally publishedYes

Fingerprint

Leptospirosis
Taiwan
Case-Control Studies
Cyclonic Storms
Leptospira
Agglutination Tests
Zoonoses
Serologic Tests
Acute Kidney Injury
Disease Outbreaks
Immunoglobulin M
Age Groups
Serum

Keywords

  • Acute renal failure
  • Leptospirosis
  • Multiple organ dysfunction

ASJC Scopus subject areas

  • Nephrology

Cite this

Yang, H. Y., Hsu, P. Y., Pan, M. J., Wu, M. S., Lee, C. H., Yu, C. C., ... Yang, C. W. (2005). Clinical distinction and evaluation of leptospirosis in Taiwan - A case-control study. Journal of Nephrology, 18(1), 45-53.

Clinical distinction and evaluation of leptospirosis in Taiwan - A case-control study. / Yang, Huang Yu; Hsu, Po Yaur; Pan, Ming Jeng; Wu, Mai Szu; Lee, Chih Hsiung; Yu, Chun Chen; Hung, Chen Chieh; Yang, Chih Wei.

In: Journal of Nephrology, Vol. 18, No. 1, 01.2005, p. 45-53.

Research output: Contribution to journalArticle

Yang, HY, Hsu, PY, Pan, MJ, Wu, MS, Lee, CH, Yu, CC, Hung, CC & Yang, CW 2005, 'Clinical distinction and evaluation of leptospirosis in Taiwan - A case-control study', Journal of Nephrology, vol. 18, no. 1, pp. 45-53.
Yang, Huang Yu ; Hsu, Po Yaur ; Pan, Ming Jeng ; Wu, Mai Szu ; Lee, Chih Hsiung ; Yu, Chun Chen ; Hung, Chen Chieh ; Yang, Chih Wei. / Clinical distinction and evaluation of leptospirosis in Taiwan - A case-control study. In: Journal of Nephrology. 2005 ; Vol. 18, No. 1. pp. 45-53.
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