Clinical considerations and surgical approaches for low-grade gliomas in deep hemispheric locations: thalamic lesions

Tai Tong Wong, Hsin Hung Chen, Muh Lii Liang, Kevin Li Chun Hsieh, Yi Shan Yang, Donald Ming Tak Ho, Kai Ping Chang, Yi Yen Lee, Shih Chieh Lin, Ting Rong Hsu, Yi Wei Chen, Sang Hue Yen, Feng Chi Chang, Wan You Guo, Kuo Wei Chen, Wei Kang Kwang, Wu Yu Hou, Chung Yih Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Tumors with epicenter in the thalamus occur in about 4�% of pediatric brain tumors. The histological diagnosis is mainly gliomas. Among them, low-grade glioma (LGG) constituted of a significant entity of the tumors (Cuccia et al., Childs Nerv Syst 13:514–521, 1997; Puget et al., J Neurosurg 106:354–362, 2007; Bernstein et al., J Neurosurg 61:649–656, 1984; Bilginer et al., Childs Nerv Syst 30:1493–1498, 2014). Since Kelly’s report in 1989, >90�% resection of thalamic tumors were achieved in reported series (Ozek and Ture, Childs Nerv Syst 18:450–6, 2002; Villarejo et al., Childs Nerv Syst 10:111–114, 1994; Moshel et al., Neurosurgery 61:66–75, 2007; Albright, J Neurosurg 100(5 Suppl Pediatrics): 468–472, 2004; Kelly, Neurosurgery 25:185–195, 1989; Drake et al., Neurosurgery 29: 27–33, 1991). Materials and methods: Sixty-nine cases of thalamic tumors in children were retrospectively reviewed. There were 25 cases of LGGs. We analyzed our experience and correlated it with reported series. Results: Summing up of 4 reported series and the present series, there were 267 cases of thalamic tumors in children. Among these tumors, 107 (40.1�%) were LGGs and 91 (34.1�%) were low-grade astrocytomas (LGAs). In the present series, all of the 25 LGGs were LGAs that consisted of 11 pilocytic astrocytomas (PAs) and 14 diffuse astrocytomas (DAs). Six cases received biopsy sampling only. The remaining 19 cases received different degrees of surgical resection via several approaches. Radical (>90�%) resection was achieved better in PAs comparing with DAs. There was no operative mortality. Two patients had increased neurological deficits. In a mean follow-up period of 11.9�years, three patients died of tumor progression and one patient died of anaplastic change. The 5- and 10-year overall survival (OS) was 87.1 and 87.1�%, respectively. Conclusion: Thalamic LGGs are mainly LGAs and are indolent. The rate of >90�% resection was relatively low in the present series. By applying contemporary diagnostic MRI studies, surgical facilities, and appropriate approaches in selective cases, we may try maximum neuroprotective radical (>90�%) resection.

Original languageEnglish
Pages (from-to)1895-1906
Number of pages12
JournalChild's Nervous System
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

Astrocytoma
Glioma
Neurosurgery
Neoplasms
Pediatrics
Thalamus
Brain Neoplasms
Biopsy
Survival
Mortality

Keywords

  • Children
  • Low-grade glioma
  • Outcome
  • Surgical approach
  • Thalamic tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Clinical considerations and surgical approaches for low-grade gliomas in deep hemispheric locations : thalamic lesions. / Wong, Tai Tong; Chen, Hsin Hung; Liang, Muh Lii; Hsieh, Kevin Li Chun; Yang, Yi Shan; Ho, Donald Ming Tak; Chang, Kai Ping; Lee, Yi Yen; Lin, Shih Chieh; Hsu, Ting Rong; Chen, Yi Wei; Yen, Sang Hue; Chang, Feng Chi; Guo, Wan You; Chen, Kuo Wei; Kwang, Wei Kang; Hou, Wu Yu; Wang, Chung Yih.

In: Child's Nervous System, Vol. 32, No. 10, 01.10.2016, p. 1895-1906.

Research output: Contribution to journalArticle

Wong, TT, Chen, HH, Liang, ML, Hsieh, KLC, Yang, YS, Ho, DMT, Chang, KP, Lee, YY, Lin, SC, Hsu, TR, Chen, YW, Yen, SH, Chang, FC, Guo, WY, Chen, KW, Kwang, WK, Hou, WY & Wang, CY 2016, 'Clinical considerations and surgical approaches for low-grade gliomas in deep hemispheric locations: thalamic lesions', Child's Nervous System, vol. 32, no. 10, pp. 1895-1906. https://doi.org/10.1007/s00381-016-3148-5
Wong, Tai Tong ; Chen, Hsin Hung ; Liang, Muh Lii ; Hsieh, Kevin Li Chun ; Yang, Yi Shan ; Ho, Donald Ming Tak ; Chang, Kai Ping ; Lee, Yi Yen ; Lin, Shih Chieh ; Hsu, Ting Rong ; Chen, Yi Wei ; Yen, Sang Hue ; Chang, Feng Chi ; Guo, Wan You ; Chen, Kuo Wei ; Kwang, Wei Kang ; Hou, Wu Yu ; Wang, Chung Yih. / Clinical considerations and surgical approaches for low-grade gliomas in deep hemispheric locations : thalamic lesions. In: Child's Nervous System. 2016 ; Vol. 32, No. 10. pp. 1895-1906.
@article{d6b8894098664686b70be09e2a6fb976,
title = "Clinical considerations and surgical approaches for low-grade gliomas in deep hemispheric locations: thalamic lesions",
abstract = "Background: Tumors with epicenter in the thalamus occur in about 4{\"i}¿½{\%} of pediatric brain tumors. The histological diagnosis is mainly gliomas. Among them, low-grade glioma (LGG) constituted of a significant entity of the tumors (Cuccia et al., Childs Nerv Syst 13:514–521, 1997; Puget et al., J Neurosurg 106:354–362, 2007; Bernstein et al., J Neurosurg 61:649–656, 1984; Bilginer et al., Childs Nerv Syst 30:1493–1498, 2014). Since Kelly’s report in 1989, >90{\"i}¿½{\%} resection of thalamic tumors were achieved in reported series (Ozek and Ture, Childs Nerv Syst 18:450–6, 2002; Villarejo et al., Childs Nerv Syst 10:111–114, 1994; Moshel et al., Neurosurgery 61:66–75, 2007; Albright, J Neurosurg 100(5 Suppl Pediatrics): 468–472, 2004; Kelly, Neurosurgery 25:185–195, 1989; Drake et al., Neurosurgery 29: 27–33, 1991). Materials and methods: Sixty-nine cases of thalamic tumors in children were retrospectively reviewed. There were 25 cases of LGGs. We analyzed our experience and correlated it with reported series. Results: Summing up of 4 reported series and the present series, there were 267 cases of thalamic tumors in children. Among these tumors, 107 (40.1{\"i}¿½{\%}) were LGGs and 91 (34.1{\"i}¿½{\%}) were low-grade astrocytomas (LGAs). In the present series, all of the 25 LGGs were LGAs that consisted of 11 pilocytic astrocytomas (PAs) and 14 diffuse astrocytomas (DAs). Six cases received biopsy sampling only. The remaining 19 cases received different degrees of surgical resection via several approaches. Radical (>90{\"i}¿½{\%}) resection was achieved better in PAs comparing with DAs. There was no operative mortality. Two patients had increased neurological deficits. In a mean follow-up period of 11.9{\"i}¿½years, three patients died of tumor progression and one patient died of anaplastic change. The 5- and 10-year overall survival (OS) was 87.1 and 87.1{\"i}¿½{\%}, respectively. Conclusion: Thalamic LGGs are mainly LGAs and are indolent. The rate of >90{\"i}¿½{\%} resection was relatively low in the present series. By applying contemporary diagnostic MRI studies, surgical facilities, and appropriate approaches in selective cases, we may try maximum neuroprotective radical (>90{\"i}¿½{\%}) resection.",
keywords = "Children, Low-grade glioma, Outcome, Surgical approach, Thalamic tumor",
author = "Wong, {Tai Tong} and Chen, {Hsin Hung} and Liang, {Muh Lii} and Hsieh, {Kevin Li Chun} and Yang, {Yi Shan} and Ho, {Donald Ming Tak} and Chang, {Kai Ping} and Lee, {Yi Yen} and Lin, {Shih Chieh} and Hsu, {Ting Rong} and Chen, {Yi Wei} and Yen, {Sang Hue} and Chang, {Feng Chi} and Guo, {Wan You} and Chen, {Kuo Wei} and Kwang, {Wei Kang} and Hou, {Wu Yu} and Wang, {Chung Yih}",
year = "2016",
month = "10",
day = "1",
doi = "10.1007/s00381-016-3148-5",
language = "English",
volume = "32",
pages = "1895--1906",
journal = "Child's Nervous System",
issn = "0256-7040",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - Clinical considerations and surgical approaches for low-grade gliomas in deep hemispheric locations

T2 - thalamic lesions

AU - Wong, Tai Tong

AU - Chen, Hsin Hung

AU - Liang, Muh Lii

AU - Hsieh, Kevin Li Chun

AU - Yang, Yi Shan

AU - Ho, Donald Ming Tak

AU - Chang, Kai Ping

AU - Lee, Yi Yen

AU - Lin, Shih Chieh

AU - Hsu, Ting Rong

AU - Chen, Yi Wei

AU - Yen, Sang Hue

AU - Chang, Feng Chi

AU - Guo, Wan You

AU - Chen, Kuo Wei

AU - Kwang, Wei Kang

AU - Hou, Wu Yu

AU - Wang, Chung Yih

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background: Tumors with epicenter in the thalamus occur in about 4�% of pediatric brain tumors. The histological diagnosis is mainly gliomas. Among them, low-grade glioma (LGG) constituted of a significant entity of the tumors (Cuccia et al., Childs Nerv Syst 13:514–521, 1997; Puget et al., J Neurosurg 106:354–362, 2007; Bernstein et al., J Neurosurg 61:649–656, 1984; Bilginer et al., Childs Nerv Syst 30:1493–1498, 2014). Since Kelly’s report in 1989, >90�% resection of thalamic tumors were achieved in reported series (Ozek and Ture, Childs Nerv Syst 18:450–6, 2002; Villarejo et al., Childs Nerv Syst 10:111–114, 1994; Moshel et al., Neurosurgery 61:66–75, 2007; Albright, J Neurosurg 100(5 Suppl Pediatrics): 468–472, 2004; Kelly, Neurosurgery 25:185–195, 1989; Drake et al., Neurosurgery 29: 27–33, 1991). Materials and methods: Sixty-nine cases of thalamic tumors in children were retrospectively reviewed. There were 25 cases of LGGs. We analyzed our experience and correlated it with reported series. Results: Summing up of 4 reported series and the present series, there were 267 cases of thalamic tumors in children. Among these tumors, 107 (40.1�%) were LGGs and 91 (34.1�%) were low-grade astrocytomas (LGAs). In the present series, all of the 25 LGGs were LGAs that consisted of 11 pilocytic astrocytomas (PAs) and 14 diffuse astrocytomas (DAs). Six cases received biopsy sampling only. The remaining 19 cases received different degrees of surgical resection via several approaches. Radical (>90�%) resection was achieved better in PAs comparing with DAs. There was no operative mortality. Two patients had increased neurological deficits. In a mean follow-up period of 11.9�years, three patients died of tumor progression and one patient died of anaplastic change. The 5- and 10-year overall survival (OS) was 87.1 and 87.1�%, respectively. Conclusion: Thalamic LGGs are mainly LGAs and are indolent. The rate of >90�% resection was relatively low in the present series. By applying contemporary diagnostic MRI studies, surgical facilities, and appropriate approaches in selective cases, we may try maximum neuroprotective radical (>90�%) resection.

AB - Background: Tumors with epicenter in the thalamus occur in about 4�% of pediatric brain tumors. The histological diagnosis is mainly gliomas. Among them, low-grade glioma (LGG) constituted of a significant entity of the tumors (Cuccia et al., Childs Nerv Syst 13:514–521, 1997; Puget et al., J Neurosurg 106:354–362, 2007; Bernstein et al., J Neurosurg 61:649–656, 1984; Bilginer et al., Childs Nerv Syst 30:1493–1498, 2014). Since Kelly’s report in 1989, >90�% resection of thalamic tumors were achieved in reported series (Ozek and Ture, Childs Nerv Syst 18:450–6, 2002; Villarejo et al., Childs Nerv Syst 10:111–114, 1994; Moshel et al., Neurosurgery 61:66–75, 2007; Albright, J Neurosurg 100(5 Suppl Pediatrics): 468–472, 2004; Kelly, Neurosurgery 25:185–195, 1989; Drake et al., Neurosurgery 29: 27–33, 1991). Materials and methods: Sixty-nine cases of thalamic tumors in children were retrospectively reviewed. There were 25 cases of LGGs. We analyzed our experience and correlated it with reported series. Results: Summing up of 4 reported series and the present series, there were 267 cases of thalamic tumors in children. Among these tumors, 107 (40.1�%) were LGGs and 91 (34.1�%) were low-grade astrocytomas (LGAs). In the present series, all of the 25 LGGs were LGAs that consisted of 11 pilocytic astrocytomas (PAs) and 14 diffuse astrocytomas (DAs). Six cases received biopsy sampling only. The remaining 19 cases received different degrees of surgical resection via several approaches. Radical (>90�%) resection was achieved better in PAs comparing with DAs. There was no operative mortality. Two patients had increased neurological deficits. In a mean follow-up period of 11.9�years, three patients died of tumor progression and one patient died of anaplastic change. The 5- and 10-year overall survival (OS) was 87.1 and 87.1�%, respectively. Conclusion: Thalamic LGGs are mainly LGAs and are indolent. The rate of >90�% resection was relatively low in the present series. By applying contemporary diagnostic MRI studies, surgical facilities, and appropriate approaches in selective cases, we may try maximum neuroprotective radical (>90�%) resection.

KW - Children

KW - Low-grade glioma

KW - Outcome

KW - Surgical approach

KW - Thalamic tumor

UR - http://www.scopus.com/inward/record.url?scp=84988452238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988452238&partnerID=8YFLogxK

U2 - 10.1007/s00381-016-3148-5

DO - 10.1007/s00381-016-3148-5

M3 - Article

C2 - 27659831

AN - SCOPUS:84988452238

VL - 32

SP - 1895

EP - 1906

JO - Child's Nervous System

JF - Child's Nervous System

SN - 0256-7040

IS - 10

ER -