Clinical characteristics of G6PD deficiency in infants with marked hyperbilirubinemia

Yi H. Weng, Ya W. Chiu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study analyzes the clinical features of glucose-6-phosphate dehydrogenase (G6PD) deficiency in infants with marked hyperbilirubinemia. We retrospectively assessed a cohort of 413 infants with peak total serum bilirubin (TSB) level ≥ 20 mg/dL from 1995 to 2007. The prevalence of G6PD deficiency was proportional to the level of peak TSB: 21.1% (81/383) in 20 mg/dL to 29.9 mg/dL, 45.5% (10/22) in 30 mg/dL to 39.9 mg/dL, and 100% (8/8) in ≥ 40 mg/dL. Male sex was more common in G6PD deficiency (75.8%). When compared with G6PD-normal infants, those with G6PD deficiency tended to have extreme hyperbilirubinemia (peak TSB level ≥ 25 mg/dL) and hemoglobin value

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • Glucose-6-phosphate dehydrogenase deficiency
  • Kernicterus
  • Neonatal hyperbilirubinemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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