Clinical application of the rapid pneumococcal urinary antigen test in the treatment of severe pneumonia in children

Huey Fung Cheong, Luo Ping Ger, Ming Ting Wu, Chih Pei Sun, Kai Sheng Hsieh, Yung Ching Liu, Ming Fang Cheng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Purpose: To evaluate the efficacy of the pneumococcal urinary antigen test (PUAT) in severe pediatric pneumonia. Methods: The study enrolled 245 pediatric patients with severe pneumonia. Patients were divided into four groups; groups 1 and 2 received PUAT, while groups 3 and 4 did not. Additionally, PUAT-positive group 1 patients were treated with penicillin, while PUAT-negative patients received ampicillin-sulbactam or cefuroxime. Group 2 patients were treated empirically without following the group 1 protocol. Group 3 patients were treated following the guideline of the Infectious Diseases Society of Taiwan (IDST), and group 4 patients were treated empirically without following the IDST guideline. Treatment was assessed by the duration of fever. Results: Treatment was most effective for group 1 and least effective for group 4. Group 2 treatment was superior to group 3 treatment. Multivariate regression analysis of groups 1 and 2 revealed that the use of PUAT (groups 1 and 2) was associated with superior response in comparison with group 4. Conclusion: Application of PUAT and adequate antimicrobial treatments in the initial stage for pediatric patients with severe pneumonia resulted in improved outcome as assessed by shortening of the duration of fever.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Volume41
Issue number1
Publication statusPublished - Feb 2008
Externally publishedYes

Keywords

  • Antigens, bacterial
  • Child
  • Pneumonia, pneumococcal
  • Predictive value of tests
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

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