Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

Chun Mao Lin, Chia Lang Fang, You Cheng Hseu, Chun Liang Chen, Jin Wun Wang, Sheng Lung Hsu, Ming Dao Tu, Shih Ting Hung, Chein Tai, Yih Huei Uen, Kai Yuan Lin

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Colon cancer is one of the most common malignant cancers worldwide but the current therapeutic approaches for advanced colon cancer are less efficient. This study investigated associations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised colon tissues from 263 patients with colon cancer. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ2 tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P = 0.0041), distant metastasis (P

Original languageEnglish
Article numbere67128
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 27 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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