Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

Chun Mao Lin; Chia Lang Fang; You Cheng Hseu; Chun Liang Chen; Jin Wun Wang; Sheng Lung Hsu; Ming Dao Tu; Shih Ting Hung; Chein Tai; Yih Huei Uen; Kai Yuan Lin

doi:10.1371/journal.pone.0067128

Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

Chun Mao Lin, Chia Lang Fang, You Cheng Hseu, Chun Liang Chen, Jin Wun Wang, Sheng Lung Hsu, Ming Dao Tu, Shih Ting Hung, Chein Tai, Yih Huei Uen, Kai Yuan Lin

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Colon cancer is one of the most common malignant cancers worldwide but the current therapeutic approaches for advanced colon cancer are less efficient. This study investigated associations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised colon tissues from 263 patients with colon cancer. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ² tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P = 0.0041), distant metastasis (P

Original language	English
Article number	e67128
Journal	PLoS One
Volume	8
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0067128
Publication status	Published - Jun 27 2013

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0067128

Cite this

@article{402b4012e5784806afef70c7bc30b7d4,

title = "Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer",

abstract = "Colon cancer is one of the most common malignant cancers worldwide but the current therapeutic approaches for advanced colon cancer are less efficient. This study investigated associations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised colon tissues from 263 patients with colon cancer. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ2 tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P = 0.0041), distant metastasis (P",

author = "Lin, {Chun Mao} and Fang, {Chia Lang} and Hseu, {You Cheng} and Chen, {Chun Liang} and Wang, {Jin Wun} and Hsu, {Sheng Lung} and Tu, {Ming Dao} and Hung, {Shih Ting} and Chein Tai and Uen, {Yih Huei} and Lin, {Kai Yuan}",

year = "2013",

month = jun,

day = "27",

doi = "10.1371/journal.pone.0067128",

language = "English",

volume = "8",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

}

TY - JOUR

T1 - Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

AU - Lin, Chun Mao

AU - Fang, Chia Lang

AU - Hseu, You Cheng

AU - Chen, Chun Liang

AU - Wang, Jin Wun

AU - Hsu, Sheng Lung

AU - Tu, Ming Dao

AU - Hung, Shih Ting

AU - Tai, Chein

AU - Uen, Yih Huei

AU - Lin, Kai Yuan

PY - 2013/6/27

Y1 - 2013/6/27

N2 - Colon cancer is one of the most common malignant cancers worldwide but the current therapeutic approaches for advanced colon cancer are less efficient. This study investigated associations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised colon tissues from 263 patients with colon cancer. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ2 tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P = 0.0041), distant metastasis (P

AB - Colon cancer is one of the most common malignant cancers worldwide but the current therapeutic approaches for advanced colon cancer are less efficient. This study investigated associations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised colon tissues from 263 patients with colon cancer. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ2 tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P = 0.0041), distant metastasis (P

UR - http://www.scopus.com/inward/record.url?scp=84879548023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879548023&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0067128

DO - 10.1371/journal.pone.0067128

M3 - Article

C2 - 23826209

AN - SCOPUS:84879548023

SN - 1932-6203

VL - 8

JO - PLoS One

JF - PLoS One

IS - 6

M1 - e67128

ER -

Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this