Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia

Han-Sun Chiang, Shauh Der Yeh, Chien Chih Wu, Boo Chung Huang, Hui Ju Tsai, Chia Lang Fang

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21 Citations (Scopus)

Abstract

Aim: To review the accumulated 30 patients with different area of Y chromosome microdeletions, focusing on their correlation with the clinical and pathological findings. Methods: A total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion. Results: There is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens. Conclusion: The clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalAsian Journal of Andrology
Volume6
Issue number4
Publication statusPublished - Dec 2004

Fingerprint

Azoospermia
Biopsy
Multiplex Polymerase Chain Reaction
Gene Deletion
Semen
Physical Examination
Spermatozoa
Counseling
Chromosomes
Pathology
Male sterility due to Y-chromosome deletions
Serum
Therapeutics

Keywords

  • Azoospermia
  • Azoospermia factor
  • Chromosome deletion
  • Male infertility
  • Oligoasthenispermia
  • Y chromosome

ASJC Scopus subject areas

  • Nephrology
  • Endocrinology

Cite this

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title = "Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia",
abstract = "Aim: To review the accumulated 30 patients with different area of Y chromosome microdeletions, focusing on their correlation with the clinical and pathological findings. Methods: A total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion. Results: There is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens. Conclusion: The clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling.",
keywords = "Azoospermia, Azoospermia factor, Chromosome deletion, Male infertility, Oligoasthenispermia, Y chromosome",
author = "Han-Sun Chiang and Yeh, {Shauh Der} and Wu, {Chien Chih} and Huang, {Boo Chung} and Tsai, {Hui Ju} and Fang, {Chia Lang}",
year = "2004",
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journal = "Asian Journal of Andrology",
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T1 - Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia

AU - Chiang, Han-Sun

AU - Yeh, Shauh Der

AU - Wu, Chien Chih

AU - Huang, Boo Chung

AU - Tsai, Hui Ju

AU - Fang, Chia Lang

PY - 2004/12

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N2 - Aim: To review the accumulated 30 patients with different area of Y chromosome microdeletions, focusing on their correlation with the clinical and pathological findings. Methods: A total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion. Results: There is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens. Conclusion: The clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling.

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