Clinical and microbiologic characteristics of Ochrobactrum anthropi bacteremia

Wen Liang Yu, Cheng Wen Lin, Der Yuan Wang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Ochrobactrerum anthropi is an oxidase-positive, nonfermenting, gram-negative bacillus that is an emerging pathogen in immunocompromised patients, particularly in those with indwelling central venous catheters. Reports of clinical manifestation of O. anthropi bacteremia are rare. Herein, we report the clinical and microbiologic characteristics of O. anthroli bacteremia in 15 patients. There were eight males and seven females, whose ages ranged from 1 month to 84 years (mean, 34 years). Ten infections were community acquired. All patients had severe underlying diseases and manifested primary O. anthropi bacteremia with no obvious focus. Only three patients had central venous catheters in place at the onset of bacteremia, but none of these showed evidence of catheter-related infection. The mean duration of fever was 4 days (range 0-11) and the mean white blood cell count was 13 x 106/L (range 5.5-28 x 109). All O. anthropi isolates tested were resistant to ampicillin, cephalothin, cefonicid, amoxicillin/clavulanic acid, piperacillin, aztreonam, and ceftazidime, and all were susceptible to gentamicin, amikacin, imipenem, ceftriaxone, and cefoperazone. Most were also susceptible to cefotaxime and moxalactam. Monotherapy with an aminoglycoside or an appropriate β-lactam (such as cefotaxime or ceftriaxone) yielded good clinical response. None of the 15 patients died directly from O. anthropi bacteremia. Our findings indicate that O. antitropi is often community acquired and can be pathogenic in critically ill or Immunocompromised patients with or without indwelling catheters. Although O. anthropi can produce clinically significant infections, the organism seems to be of relatively low virulence.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume97
Issue number2
Publication statusPublished - Feb 1998
Externally publishedYes

Fingerprint

Ochrobactrum anthropi
Bacteremia
Indwelling Catheters
Cefotaxime
Ceftriaxone
Central Venous Catheters
Immunocompromised Host
Cefonicid
Moxalactam
Community-Acquired Infections
Aztreonam
Cefoperazone
Cephalothin
Catheter-Related Infections
Amoxicillin-Potassium Clavulanate Combination
Lactams
Piperacillin
Ceftazidime
Amikacin
Imipenem

Keywords

  • Antimicrobial susceptibilitp
  • Bacteremia
  • Ochrobactrum anthropi

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical and microbiologic characteristics of Ochrobactrum anthropi bacteremia. / Yu, Wen Liang; Lin, Cheng Wen; Wang, Der Yuan.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 97, No. 2, 02.1998, p. 106-112.

Research output: Contribution to journalArticle

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