Clinical and laboratory manifestations of Kikuchi's disease in children and differences between patients with and without prolonged fever

Chih Hsien Chuang, Dah Chin Yan, Cheng Hsun Chiu, Yhu Chering Huang, Pen Yi Lin, Chin Jung Chen, Meng Hsiu Yen, Tseng Tong Kuo, Tzou Yien Lin

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Background: Kikuchi's disease (KD) is characterized by cervical lymphadenopathy with or without fever. It has been recognized worldwide but seldom reported in pediatric patients. Methods: From January 1985 through December 2001, 64 patients younger than 18 years of age with pathologic proof of KD were enrolled in this study. The clinical manifestations, laboratory data and outcomes were reviewed. Results: There were 35 male patients and 29 female patients with age ranging from 2 to 18 years and a median age of 16. All patients had cervical lymphadenopathy except 1 who had generalized lymph-adenopathy. Lymph nodes of 32 patients (50%) were painful or tender or both. Lymphadenopathy was unilateral in 52 patients (82.5%). Lymphadenopathy associated with fever was observed in 21 patients (32.8%). Other signs such as skin rash, hepatomegaly or body weight loss were less common. Twenty-six patients (40.6%) had leukopenia and 2 patients had leukocytosis. Nearly one-fourth of the patients had mild liver dysfunction. Virologic or immunologic studies were normal in most patients. Patients with prolonged fever were more likely to have leukopenia (P < 0.05). All patients recovered, but 1 developed systemic lupus erythematosus 5 years later, and the other had vasculitis syndrome 2 years later. Conclusions: The clinical presentation of KD in pediatric patients is similar to that of adults. KD is a benign, self-limiting disease; prolonged fever occurred only in 32.8% of pediatric patients in our cohort. Leukopenia was the only feature significantly associated with prolonged fever.

Original languageEnglish
Pages (from-to)551-554
Number of pages4
JournalPediatric Infectious Disease Journal
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2005
Externally publishedYes

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Histiocytic Necrotizing Lymphadenitis
Fever
Leukopenia
Pediatrics

Keywords

  • Children
  • Histiocytic necrotizing lymphadenitis
  • Kikuchi's disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Clinical and laboratory manifestations of Kikuchi's disease in children and differences between patients with and without prolonged fever. / Chuang, Chih Hsien; Yan, Dah Chin; Chiu, Cheng Hsun; Huang, Yhu Chering; Lin, Pen Yi; Chen, Chin Jung; Yen, Meng Hsiu; Kuo, Tseng Tong; Lin, Tzou Yien.

In: Pediatric Infectious Disease Journal, Vol. 24, No. 6, 06.2005, p. 551-554.

Research output: Contribution to journalReview article

Chuang, Chih Hsien ; Yan, Dah Chin ; Chiu, Cheng Hsun ; Huang, Yhu Chering ; Lin, Pen Yi ; Chen, Chin Jung ; Yen, Meng Hsiu ; Kuo, Tseng Tong ; Lin, Tzou Yien. / Clinical and laboratory manifestations of Kikuchi's disease in children and differences between patients with and without prolonged fever. In: Pediatric Infectious Disease Journal. 2005 ; Vol. 24, No. 6. pp. 551-554.
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abstract = "Background: Kikuchi's disease (KD) is characterized by cervical lymphadenopathy with or without fever. It has been recognized worldwide but seldom reported in pediatric patients. Methods: From January 1985 through December 2001, 64 patients younger than 18 years of age with pathologic proof of KD were enrolled in this study. The clinical manifestations, laboratory data and outcomes were reviewed. Results: There were 35 male patients and 29 female patients with age ranging from 2 to 18 years and a median age of 16. All patients had cervical lymphadenopathy except 1 who had generalized lymph-adenopathy. Lymph nodes of 32 patients (50{\%}) were painful or tender or both. Lymphadenopathy was unilateral in 52 patients (82.5{\%}). Lymphadenopathy associated with fever was observed in 21 patients (32.8{\%}). Other signs such as skin rash, hepatomegaly or body weight loss were less common. Twenty-six patients (40.6{\%}) had leukopenia and 2 patients had leukocytosis. Nearly one-fourth of the patients had mild liver dysfunction. Virologic or immunologic studies were normal in most patients. Patients with prolonged fever were more likely to have leukopenia (P < 0.05). All patients recovered, but 1 developed systemic lupus erythematosus 5 years later, and the other had vasculitis syndrome 2 years later. Conclusions: The clinical presentation of KD in pediatric patients is similar to that of adults. KD is a benign, self-limiting disease; prolonged fever occurred only in 32.8{\%} of pediatric patients in our cohort. Leukopenia was the only feature significantly associated with prolonged fever.",
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AU - Chuang, Chih Hsien

AU - Yan, Dah Chin

AU - Chiu, Cheng Hsun

AU - Huang, Yhu Chering

AU - Lin, Pen Yi

AU - Chen, Chin Jung

AU - Yen, Meng Hsiu

AU - Kuo, Tseng Tong

AU - Lin, Tzou Yien

PY - 2005/6

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N2 - Background: Kikuchi's disease (KD) is characterized by cervical lymphadenopathy with or without fever. It has been recognized worldwide but seldom reported in pediatric patients. Methods: From January 1985 through December 2001, 64 patients younger than 18 years of age with pathologic proof of KD were enrolled in this study. The clinical manifestations, laboratory data and outcomes were reviewed. Results: There were 35 male patients and 29 female patients with age ranging from 2 to 18 years and a median age of 16. All patients had cervical lymphadenopathy except 1 who had generalized lymph-adenopathy. Lymph nodes of 32 patients (50%) were painful or tender or both. Lymphadenopathy was unilateral in 52 patients (82.5%). Lymphadenopathy associated with fever was observed in 21 patients (32.8%). Other signs such as skin rash, hepatomegaly or body weight loss were less common. Twenty-six patients (40.6%) had leukopenia and 2 patients had leukocytosis. Nearly one-fourth of the patients had mild liver dysfunction. Virologic or immunologic studies were normal in most patients. Patients with prolonged fever were more likely to have leukopenia (P < 0.05). All patients recovered, but 1 developed systemic lupus erythematosus 5 years later, and the other had vasculitis syndrome 2 years later. Conclusions: The clinical presentation of KD in pediatric patients is similar to that of adults. KD is a benign, self-limiting disease; prolonged fever occurred only in 32.8% of pediatric patients in our cohort. Leukopenia was the only feature significantly associated with prolonged fever.

AB - Background: Kikuchi's disease (KD) is characterized by cervical lymphadenopathy with or without fever. It has been recognized worldwide but seldom reported in pediatric patients. Methods: From January 1985 through December 2001, 64 patients younger than 18 years of age with pathologic proof of KD were enrolled in this study. The clinical manifestations, laboratory data and outcomes were reviewed. Results: There were 35 male patients and 29 female patients with age ranging from 2 to 18 years and a median age of 16. All patients had cervical lymphadenopathy except 1 who had generalized lymph-adenopathy. Lymph nodes of 32 patients (50%) were painful or tender or both. Lymphadenopathy was unilateral in 52 patients (82.5%). Lymphadenopathy associated with fever was observed in 21 patients (32.8%). Other signs such as skin rash, hepatomegaly or body weight loss were less common. Twenty-six patients (40.6%) had leukopenia and 2 patients had leukocytosis. Nearly one-fourth of the patients had mild liver dysfunction. Virologic or immunologic studies were normal in most patients. Patients with prolonged fever were more likely to have leukopenia (P < 0.05). All patients recovered, but 1 developed systemic lupus erythematosus 5 years later, and the other had vasculitis syndrome 2 years later. Conclusions: The clinical presentation of KD in pediatric patients is similar to that of adults. KD is a benign, self-limiting disease; prolonged fever occurred only in 32.8% of pediatric patients in our cohort. Leukopenia was the only feature significantly associated with prolonged fever.

KW - Children

KW - Histiocytic necrotizing lymphadenitis

KW - Kikuchi's disease

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