Clinical and Genetic Factors Associated with Thiazide-Induced Hyponatremia

Chin Chou Huang, Chia Min Chung, Shuen Iu Hung, Wen Harn Pan, Hsin Bang Leu, Po Hsun Huang, Chun Chih Chiu, Liang Yu Lin, Chih Ching Lin, Chih Yu Yang, Szu Yuan Li, Yen Chia Chen, Tao Cheng Wu, Shing Jong Lin, Jaw Wen Chen

Research output: Contribution to journalArticle

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Abstract

Thiazide diuretics are associated with an increased risk of hyponatremia. The aim of this study was to investigate possible predictors of thiazide-induced hyponatremia. A total of 48 patients admitted to the ward or to the emergency department due to severe thiazide-induced hyponatremia (Na<125mmol/L) were enrolled in our study as the case group. Another 211 hypertensive patients with normal sodium levels after treatment with thiazide diuretics were selected as the control group. Twelve tag single nucleotide polymorphism markers were selected from the Potassium Channel, Inwardly Rectifying Subfamily J, Member 1 (KCNJ1) gene: rs1231254, rs2238009, rs1148058, rs675482, rs673614, rs12795437, rs2855800, rs2509585, rs3016774, rs881333, rs4529890, and rs7116606. Clinical and genetic parameters between patients with thiazide-induced hyponatremia and the control group were compared. Logistic regression was used to analyze data. The patients with thiazide-induced hyponatremia were older (P<0.001), predominantly female (P=0.008), had a lower mean body mass index (BMI) (P<0.001), and more commonly used angiotensin II receptor antagonist (P<0.001) and spironolactone (P=0.007) compared with the control groups. Analysis with multivariate logistic regression revealed that age (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.08-1.19, P<0.001), female gender (OR, 4.49; 95% CI, 1.54-13.11, P=0.006), BMI (OR, 0.80; 95% CI, 0.69-0.93, P=0.003), and KCNJ1 rs2509585C/T or T/T polymorphisms (OR, 5.75; 95% CI, 1.25-26.45, P=0.03) were independent predictors for thiazide-induced hyponatremia. Older female patients with lower BMIs and KCNJ1 rs2509585C/T or T/T polymorphisms were more likely to develop thiazide-induced hyponatremia.

Original languageEnglish
Pages (from-to)e1422
JournalMedicine (United States)
Volume94
Issue number34
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

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Thiazides
Hyponatremia
Odds Ratio
Confidence Intervals
Sodium Chloride Symporter Inhibitors
Control Groups
Body Mass Index
Logistic Models
Inwardly Rectifying Potassium Channel
Spironolactone
Angiotensin Receptor Antagonists
Single Nucleotide Polymorphism
Hospital Emergency Service
Multivariate Analysis
Sodium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Huang, C. C., Chung, C. M., Hung, S. I., Pan, W. H., Leu, H. B., Huang, P. H., ... Chen, J. W. (2015). Clinical and Genetic Factors Associated with Thiazide-Induced Hyponatremia. Medicine (United States), 94(34), e1422. https://doi.org/10.1097/MD.0000000000001422

Clinical and Genetic Factors Associated with Thiazide-Induced Hyponatremia. / Huang, Chin Chou; Chung, Chia Min; Hung, Shuen Iu; Pan, Wen Harn; Leu, Hsin Bang; Huang, Po Hsun; Chiu, Chun Chih; Lin, Liang Yu; Lin, Chih Ching; Yang, Chih Yu; Li, Szu Yuan; Chen, Yen Chia; Wu, Tao Cheng; Lin, Shing Jong; Chen, Jaw Wen.

In: Medicine (United States), Vol. 94, No. 34, 01.01.2015, p. e1422.

Research output: Contribution to journalArticle

Huang, CC, Chung, CM, Hung, SI, Pan, WH, Leu, HB, Huang, PH, Chiu, CC, Lin, LY, Lin, CC, Yang, CY, Li, SY, Chen, YC, Wu, TC, Lin, SJ & Chen, JW 2015, 'Clinical and Genetic Factors Associated with Thiazide-Induced Hyponatremia', Medicine (United States), vol. 94, no. 34, pp. e1422. https://doi.org/10.1097/MD.0000000000001422
Huang, Chin Chou ; Chung, Chia Min ; Hung, Shuen Iu ; Pan, Wen Harn ; Leu, Hsin Bang ; Huang, Po Hsun ; Chiu, Chun Chih ; Lin, Liang Yu ; Lin, Chih Ching ; Yang, Chih Yu ; Li, Szu Yuan ; Chen, Yen Chia ; Wu, Tao Cheng ; Lin, Shing Jong ; Chen, Jaw Wen. / Clinical and Genetic Factors Associated with Thiazide-Induced Hyponatremia. In: Medicine (United States). 2015 ; Vol. 94, No. 34. pp. e1422.
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