Abstract
Background: Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak.
| Original language | English |
|---|---|
| Pages (from-to) | 45-51 |
| Number of pages | 7 |
| Journal | Journal of Clinical Virology |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 2008 |
| Externally published | Yes |
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Keywords
- Acute respiratory distress syndrome
- Encephalitis/encephalopathy
- Genetic evolution
- Influenza B virus
- Influenza-associated myositis
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Virology
- Immunology and Allergy
- Infectious Diseases
Cite this
Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan. / Li, Wen Chen; Shih, Shin Ru; Huang, Yhu Chering; Chen, Guang Wu; Chang, Shih Cheng; Hsiao, Mei Jen; Tsao, Kuo Chien; Lin, Tzou Yien.
In: Journal of Clinical Virology, Vol. 42, No. 1, 05.2008, p. 45-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan
AU - Li, Wen Chen
AU - Shih, Shin Ru
AU - Huang, Yhu Chering
AU - Chen, Guang Wu
AU - Chang, Shih Cheng
AU - Hsiao, Mei Jen
AU - Tsao, Kuo Chien
AU - Lin, Tzou Yien
PY - 2008/5
Y1 - 2008/5
N2 - Background: Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak.
AB - Background: Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak.
KW - Acute respiratory distress syndrome
KW - Encephalitis/encephalopathy
KW - Genetic evolution
KW - Influenza B virus
KW - Influenza-associated myositis
UR - http://www.scopus.com/inward/record.url?scp=42649122583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42649122583&partnerID=8YFLogxK
U2 - 10.1016/j.jcv.2007.11.026
DO - 10.1016/j.jcv.2007.11.026
M3 - Article
VL - 42
SP - 45
EP - 51
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
IS - 1
ER -