TY - JOUR
T1 - Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan
AU - Li, Wen Chen
AU - Shih, Shin Ru
AU - Huang, Yhu Chering
AU - Chen, Guang Wu
AU - Chang, Shih Cheng
AU - Hsiao, Mei Jen
AU - Tsao, Kuo Chien
AU - Lin, Tzou Yien
N1 - Funding Information:
We thank all the colleagues in Chang Gung Children's Hospital and Chang Gung Memorial Hospital for the collection of clinical samples and virus identification. The study was funded by grant CMRPG450082 from Chang Gung Memorial Hospital.
PY - 2008/5
Y1 - 2008/5
N2 - Background: Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak.
AB - Background: Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak.
KW - Acute respiratory distress syndrome
KW - Encephalitis/encephalopathy
KW - Genetic evolution
KW - Influenza B virus
KW - Influenza-associated myositis
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U2 - 10.1016/j.jcv.2007.11.026
DO - 10.1016/j.jcv.2007.11.026
M3 - Article
C2 - 18325832
AN - SCOPUS:42649122583
VL - 42
SP - 45
EP - 51
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
IS - 1
ER -
