41 Citations (Scopus)

Abstract

Objective: To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS). Design: Retrospective study. Setting: University teaching hospital. Patient(s): Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls. Main Outcome Measure(s): Body mass index, average menstrual interval, modified Ferriman-Gallwey score, acne, total T, and waist-to-hip ratio. Result(s): Obese women with polycystic ovary morphology (PCOM) had a greater risk of developing of PCOS (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.5-10.4) than nonobese women with PCOM. Obese women with PCOM had a higher incidence oligomenorrhea (OR, 2.6; 95% CI, 1.6-4.1) and biochemical hyperandrogenemia (OR, 2.5; 95% CI, 1.6-4.0) than nonobese women with PCOM. Obese subjects with PCOS had a higher risk of developing oligomenorrhea (OR, 2.2; 95% CI, 1.3-3.7) and biochemical hyperandrogenemia (OR, 2.6; 95% CI, 1.6-4.2) than nonobese women with PCOS. Moreover, obese women with PCOS had significantly higher serum total T levels and more prolonged menstrual intervals than nonobese women with PCOS. Notably, the obese women with PCOS presented less acne than the nonobese subjects (OR, 0.5; 95% CI, 0.3-0.9). Conclusion(s): Obese women with PCOS had more severe ovulatory dysfunction and higher serum total T levels than nonobese subjects. Moreover, obese women with PCOS had a significantly lower frequency of acne than nonobese subjects.

Original languageEnglish
Pages (from-to)1960-1965
Number of pages6
JournalFertility and Sterility
Volume92
Issue number6
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Polycystic Ovary Syndrome
Odds Ratio
Ovary
Confidence Intervals
Acne Vulgaris
Oligomenorrhea
Waist-Hip Ratio
Serum
Taiwan
Teaching Hospitals
Body Mass Index
Retrospective Studies
Outcome Assessment (Health Care)

Keywords

  • acne
  • hirsutism
  • hyperandrogenism
  • obese
  • polycystic ovaries
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women. / Liou, Tsan-Hon; Yang, Jen Hung; Hsieh, Ching Hung; Lee, C. Y.; Hsu, Chun-Sen; Hsu, Ming-I.

In: Fertility and Sterility, Vol. 92, No. 6, 12.2009, p. 1960-1965.

Research output: Contribution to journalArticle

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title = "Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women",
abstract = "Objective: To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS). Design: Retrospective study. Setting: University teaching hospital. Patient(s): Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls. Main Outcome Measure(s): Body mass index, average menstrual interval, modified Ferriman-Gallwey score, acne, total T, and waist-to-hip ratio. Result(s): Obese women with polycystic ovary morphology (PCOM) had a greater risk of developing of PCOS (odds ratio [OR], 2.5; 95{\%} confidence interval [CI], 1.5-10.4) than nonobese women with PCOM. Obese women with PCOM had a higher incidence oligomenorrhea (OR, 2.6; 95{\%} CI, 1.6-4.1) and biochemical hyperandrogenemia (OR, 2.5; 95{\%} CI, 1.6-4.0) than nonobese women with PCOM. Obese subjects with PCOS had a higher risk of developing oligomenorrhea (OR, 2.2; 95{\%} CI, 1.3-3.7) and biochemical hyperandrogenemia (OR, 2.6; 95{\%} CI, 1.6-4.2) than nonobese women with PCOS. Moreover, obese women with PCOS had significantly higher serum total T levels and more prolonged menstrual intervals than nonobese women with PCOS. Notably, the obese women with PCOS presented less acne than the nonobese subjects (OR, 0.5; 95{\%} CI, 0.3-0.9). Conclusion(s): Obese women with PCOS had more severe ovulatory dysfunction and higher serum total T levels than nonobese subjects. Moreover, obese women with PCOS had a significantly lower frequency of acne than nonobese subjects.",
keywords = "acne, hirsutism, hyperandrogenism, obese, polycystic ovaries, Polycystic ovary syndrome",
author = "Tsan-Hon Liou and Yang, {Jen Hung} and Hsieh, {Ching Hung} and Lee, {C. Y.} and Chun-Sen Hsu and Ming-I Hsu",
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T1 - Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women

AU - Liou, Tsan-Hon

AU - Yang, Jen Hung

AU - Hsieh, Ching Hung

AU - Lee, C. Y.

AU - Hsu, Chun-Sen

AU - Hsu, Ming-I

PY - 2009/12

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N2 - Objective: To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS). Design: Retrospective study. Setting: University teaching hospital. Patient(s): Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls. Main Outcome Measure(s): Body mass index, average menstrual interval, modified Ferriman-Gallwey score, acne, total T, and waist-to-hip ratio. Result(s): Obese women with polycystic ovary morphology (PCOM) had a greater risk of developing of PCOS (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.5-10.4) than nonobese women with PCOM. Obese women with PCOM had a higher incidence oligomenorrhea (OR, 2.6; 95% CI, 1.6-4.1) and biochemical hyperandrogenemia (OR, 2.5; 95% CI, 1.6-4.0) than nonobese women with PCOM. Obese subjects with PCOS had a higher risk of developing oligomenorrhea (OR, 2.2; 95% CI, 1.3-3.7) and biochemical hyperandrogenemia (OR, 2.6; 95% CI, 1.6-4.2) than nonobese women with PCOS. Moreover, obese women with PCOS had significantly higher serum total T levels and more prolonged menstrual intervals than nonobese women with PCOS. Notably, the obese women with PCOS presented less acne than the nonobese subjects (OR, 0.5; 95% CI, 0.3-0.9). Conclusion(s): Obese women with PCOS had more severe ovulatory dysfunction and higher serum total T levels than nonobese subjects. Moreover, obese women with PCOS had a significantly lower frequency of acne than nonobese subjects.

AB - Objective: To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS). Design: Retrospective study. Setting: University teaching hospital. Patient(s): Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls. Main Outcome Measure(s): Body mass index, average menstrual interval, modified Ferriman-Gallwey score, acne, total T, and waist-to-hip ratio. Result(s): Obese women with polycystic ovary morphology (PCOM) had a greater risk of developing of PCOS (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.5-10.4) than nonobese women with PCOM. Obese women with PCOM had a higher incidence oligomenorrhea (OR, 2.6; 95% CI, 1.6-4.1) and biochemical hyperandrogenemia (OR, 2.5; 95% CI, 1.6-4.0) than nonobese women with PCOM. Obese subjects with PCOS had a higher risk of developing oligomenorrhea (OR, 2.2; 95% CI, 1.3-3.7) and biochemical hyperandrogenemia (OR, 2.6; 95% CI, 1.6-4.2) than nonobese women with PCOS. Moreover, obese women with PCOS had significantly higher serum total T levels and more prolonged menstrual intervals than nonobese women with PCOS. Notably, the obese women with PCOS presented less acne than the nonobese subjects (OR, 0.5; 95% CI, 0.3-0.9). Conclusion(s): Obese women with PCOS had more severe ovulatory dysfunction and higher serum total T levels than nonobese subjects. Moreover, obese women with PCOS had a significantly lower frequency of acne than nonobese subjects.

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KW - hirsutism

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KW - polycystic ovaries

KW - Polycystic ovary syndrome

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