Clinical and biochemical presentation of polycystic ovary syndrome in women between the ages of 20 and 40

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Abstract

Background: The clinical features and metabolic complications of polycystic ovary syndrome (PCOS) may change with age. This study was designed to investigate the clinical and biochemical characteristics of PCOS patients between the ages of 20 and 40.Methods: The study included 781 Taiwanese women, of whom 453 were diagnosed with PCOS and 328 were non-PCOS controls. Anthroponmetric components, androgens, endocrine, insulin resistance, and metabolic components were measured and correlated with age. Above parameters were compared between younger and elder women with PCOS.Results: Age had significant negative correlations with androgens (total testosterone and dehydroepiandrosterone sulfate), the modified FerrimanGallwey score and the prevalence of acne and hirsutism. Age had significant positive correlations with fasting glucose, cholesterol, triglycerides and low-density lipoprotein. The 453 women who fulfilled diagnostic criteria for PCOS were classified by age into two groups: Group A (2029 years old, n 294) and Group B (3040 years old, n 159). Group A had significantly higher total testosterone levels than Group B. Group B had higher fasting insulin and glucose levels, triglycerides, body mass index and waist measurements and a higher incidence of obesity than Group A. The average ovarian volume was not significantly different among the two groups. Conclusions: Increased age is accompanied by a decrease in the prevalence of both clinical and biochemical hyperandrogenism in women. Hyperandrogenism is the important factor for young women with PCOS; however, abdominal obesity and certain metabolic disturbances became major concerns for older women with PCOS.

Original languageEnglish
Pages (from-to)3443-3449
Number of pages7
JournalHuman Reproduction
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Polycystic Ovary Syndrome
Hyperandrogenism
Androgens
Testosterone
Fasting
Glucose
Hirsutism
Dehydroepiandrosterone Sulfate
Abdominal Obesity
Acne Vulgaris
LDL Cholesterol
Insulin Resistance
Ovary
Triglycerides
Body Mass Index
Obesity
Insulin
Incidence

Keywords

  • age
  • hyperandrogenism
  • metabolic syndrome
  • polycystic ovary syndrome

ASJC Scopus subject areas

  • Rehabilitation
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

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title = "Clinical and biochemical presentation of polycystic ovary syndrome in women between the ages of 20 and 40",
abstract = "Background: The clinical features and metabolic complications of polycystic ovary syndrome (PCOS) may change with age. This study was designed to investigate the clinical and biochemical characteristics of PCOS patients between the ages of 20 and 40.Methods: The study included 781 Taiwanese women, of whom 453 were diagnosed with PCOS and 328 were non-PCOS controls. Anthroponmetric components, androgens, endocrine, insulin resistance, and metabolic components were measured and correlated with age. Above parameters were compared between younger and elder women with PCOS.Results: Age had significant negative correlations with androgens (total testosterone and dehydroepiandrosterone sulfate), the modified FerrimanGallwey score and the prevalence of acne and hirsutism. Age had significant positive correlations with fasting glucose, cholesterol, triglycerides and low-density lipoprotein. The 453 women who fulfilled diagnostic criteria for PCOS were classified by age into two groups: Group A (2029 years old, n 294) and Group B (3040 years old, n 159). Group A had significantly higher total testosterone levels than Group B. Group B had higher fasting insulin and glucose levels, triglycerides, body mass index and waist measurements and a higher incidence of obesity than Group A. The average ovarian volume was not significantly different among the two groups. Conclusions: Increased age is accompanied by a decrease in the prevalence of both clinical and biochemical hyperandrogenism in women. Hyperandrogenism is the important factor for young women with PCOS; however, abdominal obesity and certain metabolic disturbances became major concerns for older women with PCOS.",
keywords = "age, hyperandrogenism, metabolic syndrome, polycystic ovary syndrome",
author = "Liang, {So Jung} and Chun-Sen Hsu and Tzeng, {Chii Ruey} and Chen, {Chi Huang} and Hsu, {Ming I.}",
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AU - Liang, So Jung

AU - Hsu, Chun-Sen

AU - Tzeng, Chii Ruey

AU - Chen, Chi Huang

AU - Hsu, Ming I.

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N2 - Background: The clinical features and metabolic complications of polycystic ovary syndrome (PCOS) may change with age. This study was designed to investigate the clinical and biochemical characteristics of PCOS patients between the ages of 20 and 40.Methods: The study included 781 Taiwanese women, of whom 453 were diagnosed with PCOS and 328 were non-PCOS controls. Anthroponmetric components, androgens, endocrine, insulin resistance, and metabolic components were measured and correlated with age. Above parameters were compared between younger and elder women with PCOS.Results: Age had significant negative correlations with androgens (total testosterone and dehydroepiandrosterone sulfate), the modified FerrimanGallwey score and the prevalence of acne and hirsutism. Age had significant positive correlations with fasting glucose, cholesterol, triglycerides and low-density lipoprotein. The 453 women who fulfilled diagnostic criteria for PCOS were classified by age into two groups: Group A (2029 years old, n 294) and Group B (3040 years old, n 159). Group A had significantly higher total testosterone levels than Group B. Group B had higher fasting insulin and glucose levels, triglycerides, body mass index and waist measurements and a higher incidence of obesity than Group A. The average ovarian volume was not significantly different among the two groups. Conclusions: Increased age is accompanied by a decrease in the prevalence of both clinical and biochemical hyperandrogenism in women. Hyperandrogenism is the important factor for young women with PCOS; however, abdominal obesity and certain metabolic disturbances became major concerns for older women with PCOS.

AB - Background: The clinical features and metabolic complications of polycystic ovary syndrome (PCOS) may change with age. This study was designed to investigate the clinical and biochemical characteristics of PCOS patients between the ages of 20 and 40.Methods: The study included 781 Taiwanese women, of whom 453 were diagnosed with PCOS and 328 were non-PCOS controls. Anthroponmetric components, androgens, endocrine, insulin resistance, and metabolic components were measured and correlated with age. Above parameters were compared between younger and elder women with PCOS.Results: Age had significant negative correlations with androgens (total testosterone and dehydroepiandrosterone sulfate), the modified FerrimanGallwey score and the prevalence of acne and hirsutism. Age had significant positive correlations with fasting glucose, cholesterol, triglycerides and low-density lipoprotein. The 453 women who fulfilled diagnostic criteria for PCOS were classified by age into two groups: Group A (2029 years old, n 294) and Group B (3040 years old, n 159). Group A had significantly higher total testosterone levels than Group B. Group B had higher fasting insulin and glucose levels, triglycerides, body mass index and waist measurements and a higher incidence of obesity than Group A. The average ovarian volume was not significantly different among the two groups. Conclusions: Increased age is accompanied by a decrease in the prevalence of both clinical and biochemical hyperandrogenism in women. Hyperandrogenism is the important factor for young women with PCOS; however, abdominal obesity and certain metabolic disturbances became major concerns for older women with PCOS.

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