Abstract

Background and objectives: Lung cancer is the leading cause of cancer deaths worldwide. With current use of autofluorescent bronchoscopic imaging to detect early lung cancer and limitations of pathologic examinations, a computer-aided diagnosis (CAD) system based on autofluorescent bronchoscopy was proposed to distinguish different pathological cancer types to achieve objective and consistent diagnoses. Methods: The collected database consisted of 12 adenocarcinomas and 11 squamous cell carcinomas. The corresponding autofluorescent bronchoscopic images were first transformed to a hue (H), saturation (S), and value (V) color space to obtain better interpretation of the color information. Color textural features were respectively extracted from the H, S, and V channels and combined in a logistic regression classifier to classify malignant types by machine learning. Results: After feature selection, the proposed CAD system achieved an accuracy of 83% (19/23), a sensitivity of 73% (8/11), a specificity of 92% (11/12), a positive predictive value of 89% (8/9), a negative predictive value of 79% (11/14), and an area under the receiver operating characteristic curve of 0.81 for distinguishing lung cancer types. Conclusions: The proposed CAD system based on color textures of autofluorescent bronchoscopic images provides a diagnostic method of malignant types in clinical use.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalComputer Methods and Programs in Biomedicine
Volume163
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Computer aided diagnosis
Pattern recognition
Lung Neoplasms
Color
Bronchoscopy
ROC Curve
Learning systems
Logistics
Feature extraction
Cause of Death
Squamous Cell Carcinoma
Neoplasms
Adenocarcinoma
Classifiers
Textures
Logistic Models
Databases
Imaging techniques

Keywords

  • Autofluorescent bronchoscopy
  • Color texture
  • Computer-aided diagnosis
  • Lung cancer

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics

Cite this

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title = "Classification of lung cancer subtypes based on autofluorescence bronchoscopic pattern recognition: A preliminary study",
abstract = "Background and objectives: Lung cancer is the leading cause of cancer deaths worldwide. With current use of autofluorescent bronchoscopic imaging to detect early lung cancer and limitations of pathologic examinations, a computer-aided diagnosis (CAD) system based on autofluorescent bronchoscopy was proposed to distinguish different pathological cancer types to achieve objective and consistent diagnoses. Methods: The collected database consisted of 12 adenocarcinomas and 11 squamous cell carcinomas. The corresponding autofluorescent bronchoscopic images were first transformed to a hue (H), saturation (S), and value (V) color space to obtain better interpretation of the color information. Color textural features were respectively extracted from the H, S, and V channels and combined in a logistic regression classifier to classify malignant types by machine learning. Results: After feature selection, the proposed CAD system achieved an accuracy of 83{\%} (19/23), a sensitivity of 73{\%} (8/11), a specificity of 92{\%} (11/12), a positive predictive value of 89{\%} (8/9), a negative predictive value of 79{\%} (11/14), and an area under the receiver operating characteristic curve of 0.81 for distinguishing lung cancer types. Conclusions: The proposed CAD system based on color textures of autofluorescent bronchoscopic images provides a diagnostic method of malignant types in clinical use.",
keywords = "Autofluorescent bronchoscopy, Color texture, Computer-aided diagnosis, Lung cancer",
author = "Feng, {Po Hao} and Chen, {Tzu Tao} and Lin, {Yin Tzu} and Chiang, {Shang Yu} and Lo, {Chung Ming}",
year = "2018",
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language = "English",
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T1 - Classification of lung cancer subtypes based on autofluorescence bronchoscopic pattern recognition

T2 - A preliminary study

AU - Feng, Po Hao

AU - Chen, Tzu Tao

AU - Lin, Yin Tzu

AU - Chiang, Shang Yu

AU - Lo, Chung Ming

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background and objectives: Lung cancer is the leading cause of cancer deaths worldwide. With current use of autofluorescent bronchoscopic imaging to detect early lung cancer and limitations of pathologic examinations, a computer-aided diagnosis (CAD) system based on autofluorescent bronchoscopy was proposed to distinguish different pathological cancer types to achieve objective and consistent diagnoses. Methods: The collected database consisted of 12 adenocarcinomas and 11 squamous cell carcinomas. The corresponding autofluorescent bronchoscopic images were first transformed to a hue (H), saturation (S), and value (V) color space to obtain better interpretation of the color information. Color textural features were respectively extracted from the H, S, and V channels and combined in a logistic regression classifier to classify malignant types by machine learning. Results: After feature selection, the proposed CAD system achieved an accuracy of 83% (19/23), a sensitivity of 73% (8/11), a specificity of 92% (11/12), a positive predictive value of 89% (8/9), a negative predictive value of 79% (11/14), and an area under the receiver operating characteristic curve of 0.81 for distinguishing lung cancer types. Conclusions: The proposed CAD system based on color textures of autofluorescent bronchoscopic images provides a diagnostic method of malignant types in clinical use.

AB - Background and objectives: Lung cancer is the leading cause of cancer deaths worldwide. With current use of autofluorescent bronchoscopic imaging to detect early lung cancer and limitations of pathologic examinations, a computer-aided diagnosis (CAD) system based on autofluorescent bronchoscopy was proposed to distinguish different pathological cancer types to achieve objective and consistent diagnoses. Methods: The collected database consisted of 12 adenocarcinomas and 11 squamous cell carcinomas. The corresponding autofluorescent bronchoscopic images were first transformed to a hue (H), saturation (S), and value (V) color space to obtain better interpretation of the color information. Color textural features were respectively extracted from the H, S, and V channels and combined in a logistic regression classifier to classify malignant types by machine learning. Results: After feature selection, the proposed CAD system achieved an accuracy of 83% (19/23), a sensitivity of 73% (8/11), a specificity of 92% (11/12), a positive predictive value of 89% (8/9), a negative predictive value of 79% (11/14), and an area under the receiver operating characteristic curve of 0.81 for distinguishing lung cancer types. Conclusions: The proposed CAD system based on color textures of autofluorescent bronchoscopic images provides a diagnostic method of malignant types in clinical use.

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