CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of Stat3 activation

Yu Ching Lin, Ming Szu Hung, Chin Kuo Lin, Jhy Ming Li, Kuan Der Lee, Ya Chin Li, Miao Fen Chen, Jan Kan Chen, Cheng Ta Yang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

CK2 interacts and phosphorylates >300 proteins, including Stat3, and is linked to a number of human cancers. Constitutively activated Stat3 has been reported in 50% of human lung cancers. Inhibition of CK2 activity can induce apoptosis and suppression of Stat3 activation in cancer cells. This study examined the effects of CK2 inhibitors on growth inhibition of lung cancer cells and the therapeutic potential on lung cancer. The CK2 inhibitor and radiation both suppressed cancer cell growth in a dose-dependent manner. Besides, the cytotoxic effect of irradiation could be augmented by CK2 inhibitors (p<0.05, two-way analysis of variance and Tukey's Honestly Significant Difference). Moreover, the growth inhibition of CK2 inhibitor and irradiation was both associated with suppression of Stat3 activation. Taken together, inhibition of CK2 activity appears to be a promising treatment strategy for non-small cell lung cancer and CK2 inhibition results in reduced Stat3 activation. Our data warrant further effort to develop CK2-targeted radiosensitizer for lung cancer treatment.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalCancer Biotherapy and Radiopharmaceuticals
Volume26
Issue number3
DOIs
Publication statusPublished - Jun 1 2011
Externally publishedYes

Keywords

  • CK2
  • Irradiation
  • non-small cell lung cancer
  • Stat3

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology
  • Cancer Research

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