Cisplatin plus vinorelbine (PVn) as a palliative regimen beyond second line for advanced breast cancer - A single institute experience

Yi Feng Wu, Tso Fu Wang, Sung Chao Chu, Kuan Po Huang, Chao Yuan Yo, Szu Chin Li, Chi Cheng Lee, Ruey Ho Kao

Research output: Contribution to journalArticle

Abstract

Objectives: The combination of cisplatin and vinorelbine has been proved to be effective and safe in the therapy of advanced breast cancer. We reported the experience of treating advanced breast cancer with combination of cisplatin and vinorelbine (PVn) as second line palliative regimen in Hualien Buddhist Tzu Chi General Hospital. Study design: Retrospectively, we analyzed thirty patients who underwent the regimen of PVn between Oct. 2002 and Sep. 2008. Patients received cisplatin (75mg/m2) on day 1 and vinorelbine (25mg/m2) on day 1 and 8 by intravenous infusion in every three weeks. Treatment was repeated for up to six cycles. The effectiveness and complications of the regimen were analyzed. Results: Among 30 patients, there were 21 patients with objective responses (70%), including 4 complete responses (13.3%) and 17 partial responses (56.7%). Time to progression was 7.79 months, and overall survival was 13.2 months. Grade 3 or 4 neutropenia was observed in 15 patients (63.3%), and neutropenic fever developed in 11 patients (36.7%). There was no treatment-related mortality. Conclusion: The combination of cisplatin and vinorelbine is effective and with modest toxicity as a palliative regimen in advanced breast cancer.

Original languageEnglish
Pages (from-to)344-351
Number of pages8
JournalJournal of Internal Medicine of Taiwan
Volume22
Issue number5
Publication statusPublished - Oct 1 2011
Externally publishedYes

    Fingerprint

Keywords

  • Advanced breast cancer
  • Chemotherapy
  • Cisplatin
  • Palliative
  • Vinorelbine

ASJC Scopus subject areas

  • Internal Medicine

Cite this