Cisd2 mediates mitochondrial integrity and life span in mammals

Yi Fan Chen, Cheng Heng Kao, Ralph Kirby, Ting Fen Tsai

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals.

Original languageEnglish
Pages (from-to)1043-1045
Number of pages3
JournalAutophagy
Volume5
Issue number7
DOIs
Publication statusPublished - Oct 1 2009
Externally publishedYes

Fingerprint

Mammals
Premature Aging
Nerve Degeneration
Mitochondrial Genes
Autophagy
Genes
Muscles
Wolfram Syndrome 2

Keywords

  • Autophagy
  • Cisd2
  • Knockout mice
  • Mitochondria
  • Premature aging

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Cisd2 mediates mitochondrial integrity and life span in mammals. / Chen, Yi Fan; Kao, Cheng Heng; Kirby, Ralph; Tsai, Ting Fen.

In: Autophagy, Vol. 5, No. 7, 01.10.2009, p. 1043-1045.

Research output: Contribution to journalReview article

Chen, Yi Fan ; Kao, Cheng Heng ; Kirby, Ralph ; Tsai, Ting Fen. / Cisd2 mediates mitochondrial integrity and life span in mammals. In: Autophagy. 2009 ; Vol. 5, No. 7. pp. 1043-1045.
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