Cirrhotic patients at increased risk of peptic ulcer bleeding

A nationwide population-based cohort study

J. C. Luo, H. B. Leu, M. C. Hou, C. C. Huang, H. C. Lin, F. Y. Lee, F. Y. Chang, W. L. Chan, S. J. Lin, J. W. Chen

Research output: Contribution to journalArticle

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Abstract

Background: Few large population-based studies have compared the occurrence of peptic ulcer bleeding (PUB) in cirrhotic and noncirrhotic patients. Aims: To investigate if cirrhotic patients have higher risk of PUB than the general population and to identify possible risk factors of PUB in cirrhotic patients. Methods: Using the National Health Insurance Research Database, a nationwide population-based dataset in Taiwan and matching age, gender, comorbidities and ulcerogenic medication by propensity score, 4013 cirrhotic patients, 8013 chronic hepatitis patients and 7793 normal controls were compared. The log-rank test was used to analyse differences in accumulated PUB-free survival rates between the groups. Cox proportional hazard regressions were performed to evaluate independent risk factors for PUB in all patients and identified risk factors of PUB in cirrhotic patients. Results: During the 7-year follow-up, cirrhotic patients had significantly higher incidences of PUB than chronic hepatitis patients and controls, respectively (P <0.001 by log-rank test). By Cox proportional hazard regression analysis, cirrhosis was independently associated with increased risk of PUB (hazard ratio: 4.22; 95% CI 3.37-5.29, P <0.001) after adjusting for age, gender, economic status, underlying comorbidities and ulcerogenic medication. Age, male, diabetes, chronic renal disease, history of gastro-oesophageal variceal bleeding and use of nonsteroidal anti-inflammatory drugs were risk factors for PUB in cirrhotic patients. Conclusion: Cirrhotic patients have a significantly higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like age, gender, economic status, underlying comorbidities and ulcerogenic medication.

Original languageEnglish
Pages (from-to)542-550
Number of pages9
JournalAlimentary Pharmacology and Therapeutics
Volume36
Issue number6
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

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Peptic Ulcer
Cohort Studies
Hemorrhage
Population
Comorbidity
Chronic Hepatitis
Economics
Propensity Score
Age Factors
National Health Programs
Taiwan
Chronic Renal Insufficiency
Fibrosis
Anti-Inflammatory Agents
Survival Rate
Regression Analysis
Databases
Incidence

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Cirrhotic patients at increased risk of peptic ulcer bleeding : A nationwide population-based cohort study. / Luo, J. C.; Leu, H. B.; Hou, M. C.; Huang, C. C.; Lin, H. C.; Lee, F. Y.; Chang, F. Y.; Chan, W. L.; Lin, S. J.; Chen, J. W.

In: Alimentary Pharmacology and Therapeutics, Vol. 36, No. 6, 09.2012, p. 542-550.

Research output: Contribution to journalArticle

Luo, J. C. ; Leu, H. B. ; Hou, M. C. ; Huang, C. C. ; Lin, H. C. ; Lee, F. Y. ; Chang, F. Y. ; Chan, W. L. ; Lin, S. J. ; Chen, J. W. / Cirrhotic patients at increased risk of peptic ulcer bleeding : A nationwide population-based cohort study. In: Alimentary Pharmacology and Therapeutics. 2012 ; Vol. 36, No. 6. pp. 542-550.
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abstract = "Background: Few large population-based studies have compared the occurrence of peptic ulcer bleeding (PUB) in cirrhotic and noncirrhotic patients. Aims: To investigate if cirrhotic patients have higher risk of PUB than the general population and to identify possible risk factors of PUB in cirrhotic patients. Methods: Using the National Health Insurance Research Database, a nationwide population-based dataset in Taiwan and matching age, gender, comorbidities and ulcerogenic medication by propensity score, 4013 cirrhotic patients, 8013 chronic hepatitis patients and 7793 normal controls were compared. The log-rank test was used to analyse differences in accumulated PUB-free survival rates between the groups. Cox proportional hazard regressions were performed to evaluate independent risk factors for PUB in all patients and identified risk factors of PUB in cirrhotic patients. Results: During the 7-year follow-up, cirrhotic patients had significantly higher incidences of PUB than chronic hepatitis patients and controls, respectively (P <0.001 by log-rank test). By Cox proportional hazard regression analysis, cirrhosis was independently associated with increased risk of PUB (hazard ratio: 4.22; 95{\%} CI 3.37-5.29, P <0.001) after adjusting for age, gender, economic status, underlying comorbidities and ulcerogenic medication. Age, male, diabetes, chronic renal disease, history of gastro-oesophageal variceal bleeding and use of nonsteroidal anti-inflammatory drugs were risk factors for PUB in cirrhotic patients. Conclusion: Cirrhotic patients have a significantly higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like age, gender, economic status, underlying comorbidities and ulcerogenic medication.",
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T1 - Cirrhotic patients at increased risk of peptic ulcer bleeding

T2 - A nationwide population-based cohort study

AU - Luo, J. C.

AU - Leu, H. B.

AU - Hou, M. C.

AU - Huang, C. C.

AU - Lin, H. C.

AU - Lee, F. Y.

AU - Chang, F. Y.

AU - Chan, W. L.

AU - Lin, S. J.

AU - Chen, J. W.

PY - 2012/9

Y1 - 2012/9

N2 - Background: Few large population-based studies have compared the occurrence of peptic ulcer bleeding (PUB) in cirrhotic and noncirrhotic patients. Aims: To investigate if cirrhotic patients have higher risk of PUB than the general population and to identify possible risk factors of PUB in cirrhotic patients. Methods: Using the National Health Insurance Research Database, a nationwide population-based dataset in Taiwan and matching age, gender, comorbidities and ulcerogenic medication by propensity score, 4013 cirrhotic patients, 8013 chronic hepatitis patients and 7793 normal controls were compared. The log-rank test was used to analyse differences in accumulated PUB-free survival rates between the groups. Cox proportional hazard regressions were performed to evaluate independent risk factors for PUB in all patients and identified risk factors of PUB in cirrhotic patients. Results: During the 7-year follow-up, cirrhotic patients had significantly higher incidences of PUB than chronic hepatitis patients and controls, respectively (P <0.001 by log-rank test). By Cox proportional hazard regression analysis, cirrhosis was independently associated with increased risk of PUB (hazard ratio: 4.22; 95% CI 3.37-5.29, P <0.001) after adjusting for age, gender, economic status, underlying comorbidities and ulcerogenic medication. Age, male, diabetes, chronic renal disease, history of gastro-oesophageal variceal bleeding and use of nonsteroidal anti-inflammatory drugs were risk factors for PUB in cirrhotic patients. Conclusion: Cirrhotic patients have a significantly higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like age, gender, economic status, underlying comorbidities and ulcerogenic medication.

AB - Background: Few large population-based studies have compared the occurrence of peptic ulcer bleeding (PUB) in cirrhotic and noncirrhotic patients. Aims: To investigate if cirrhotic patients have higher risk of PUB than the general population and to identify possible risk factors of PUB in cirrhotic patients. Methods: Using the National Health Insurance Research Database, a nationwide population-based dataset in Taiwan and matching age, gender, comorbidities and ulcerogenic medication by propensity score, 4013 cirrhotic patients, 8013 chronic hepatitis patients and 7793 normal controls were compared. The log-rank test was used to analyse differences in accumulated PUB-free survival rates between the groups. Cox proportional hazard regressions were performed to evaluate independent risk factors for PUB in all patients and identified risk factors of PUB in cirrhotic patients. Results: During the 7-year follow-up, cirrhotic patients had significantly higher incidences of PUB than chronic hepatitis patients and controls, respectively (P <0.001 by log-rank test). By Cox proportional hazard regression analysis, cirrhosis was independently associated with increased risk of PUB (hazard ratio: 4.22; 95% CI 3.37-5.29, P <0.001) after adjusting for age, gender, economic status, underlying comorbidities and ulcerogenic medication. Age, male, diabetes, chronic renal disease, history of gastro-oesophageal variceal bleeding and use of nonsteroidal anti-inflammatory drugs were risk factors for PUB in cirrhotic patients. Conclusion: Cirrhotic patients have a significantly higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like age, gender, economic status, underlying comorbidities and ulcerogenic medication.

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