Circulation of donor lymphocytes after blood transfusion in man

G. P. Schechter, J. Whang Peng, W. McFarland

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Atypical lymphocytes (ATL) appear in the circulation of a large proportion of patients during the first week following a blood transfusion. In order to determine the source of these ATL, cytogenetic studies were performed on the peripheral blood leukocytes of ten adult patients who received fresh blood from donors of the opposite sex. Nine of the ten patients had spontaneously dividing mononuclear cells of the recipient or host karyotype circulating during the latter part of the first week after transfusion. In two patients, the spontaneously dividing cells were of donor as well as of host origin. Six patients had circulating phytohemagglutinin-responsive lymphocytes of the donor karyotype noted from 1-7 days after transfusion. These findings lend support to our hypothesis that the increase in circulating atypical lymphocytes seen 1 wk after transfusion represents the counterpart in vivo of the in vitro mixed leukocyte reaction. The dividing donor cells may represent a subclinical graft-versus-host reaction.

Original languageEnglish
Pages (from-to)651-656
Number of pages6
JournalBlood
Volume49
Issue number4
Publication statusPublished - Dec 1 1977
Externally publishedYes

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Lymphocytes
Blood Transfusion
Blood
Tissue Donors
Graft vs. host reactions
Karyotype
Phytohemagglutinins
Mixed Lymphocyte Culture Test
Blood Donors
Cytogenetics
Leukocytes
Transplants

ASJC Scopus subject areas

  • Hematology

Cite this

Schechter, G. P., Whang Peng, J., & McFarland, W. (1977). Circulation of donor lymphocytes after blood transfusion in man. Blood, 49(4), 651-656.

Circulation of donor lymphocytes after blood transfusion in man. / Schechter, G. P.; Whang Peng, J.; McFarland, W.

In: Blood, Vol. 49, No. 4, 01.12.1977, p. 651-656.

Research output: Contribution to journalArticle

Schechter, GP, Whang Peng, J & McFarland, W 1977, 'Circulation of donor lymphocytes after blood transfusion in man', Blood, vol. 49, no. 4, pp. 651-656.
Schechter GP, Whang Peng J, McFarland W. Circulation of donor lymphocytes after blood transfusion in man. Blood. 1977 Dec 1;49(4):651-656.
Schechter, G. P. ; Whang Peng, J. ; McFarland, W. / Circulation of donor lymphocytes after blood transfusion in man. In: Blood. 1977 ; Vol. 49, No. 4. pp. 651-656.
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