Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes

Sheng Chiang Su, Dee Pei, Chang Hsun Hsieh, Fone Ching Hsiao, Chung Ze Wu, Yi Jen Hung

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI 25 kg/m 2, N = 23) and an obese group (OBYDM, BMI 25 kg/m 2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-β, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P <0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P <0.01 and P <0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-α levels in OBYDM, whereas higher TNF-α and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = -0.44, P <0.005), CRP (R = 0.28, P <0.05), TNF-α (R = 0.42, P <0.005) and IL-6 (R = 0.33, P <0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = -0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalActa Diabetologica
Volume48
Issue number2
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Adiponectin
Type 2 Diabetes Mellitus
Cytokines
Tumor Necrosis Factor-alpha
C-Reactive Protein
Interleukin-6
Insulin Resistance
Fasting
Glycemic Index
Hemoglobins
Body Mass Index
Homeostasis
Insulin
Lipids

Keywords

  • Adiponectin
  • Pro-inflammatory cytokines
  • Young diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes. / Su, Sheng Chiang; Pei, Dee; Hsieh, Chang Hsun; Hsiao, Fone Ching; Wu, Chung Ze; Hung, Yi Jen.

In: Acta Diabetologica, Vol. 48, No. 2, 06.2011, p. 113-119.

Research output: Contribution to journalArticle

Su, Sheng Chiang ; Pei, Dee ; Hsieh, Chang Hsun ; Hsiao, Fone Ching ; Wu, Chung Ze ; Hung, Yi Jen. / Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes. In: Acta Diabetologica. 2011 ; Vol. 48, No. 2. pp. 113-119.
@article{f5f0550283284501a61e779857604a2d,
title = "Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes",
abstract = "This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI 25 kg/m 2, N = 23) and an obese group (OBYDM, BMI 25 kg/m 2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-β, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P <0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P <0.01 and P <0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-α levels in OBYDM, whereas higher TNF-α and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = -0.44, P <0.005), CRP (R = 0.28, P <0.05), TNF-α (R = 0.42, P <0.005) and IL-6 (R = 0.33, P <0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = -0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.",
keywords = "Adiponectin, Pro-inflammatory cytokines, Young diabetes",
author = "Su, {Sheng Chiang} and Dee Pei and Hsieh, {Chang Hsun} and Hsiao, {Fone Ching} and Wu, {Chung Ze} and Hung, {Yi Jen}",
year = "2011",
month = "6",
doi = "10.1007/s00592-009-0171-y",
language = "English",
volume = "48",
pages = "113--119",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia",
number = "2",

}

TY - JOUR

T1 - Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes

AU - Su, Sheng Chiang

AU - Pei, Dee

AU - Hsieh, Chang Hsun

AU - Hsiao, Fone Ching

AU - Wu, Chung Ze

AU - Hung, Yi Jen

PY - 2011/6

Y1 - 2011/6

N2 - This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI 25 kg/m 2, N = 23) and an obese group (OBYDM, BMI 25 kg/m 2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-β, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P <0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P <0.01 and P <0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-α levels in OBYDM, whereas higher TNF-α and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = -0.44, P <0.005), CRP (R = 0.28, P <0.05), TNF-α (R = 0.42, P <0.005) and IL-6 (R = 0.33, P <0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = -0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.

AB - This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI 25 kg/m 2, N = 23) and an obese group (OBYDM, BMI 25 kg/m 2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-β, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P <0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P <0.01 and P <0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-α levels in OBYDM, whereas higher TNF-α and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = -0.44, P <0.005), CRP (R = 0.28, P <0.05), TNF-α (R = 0.42, P <0.005) and IL-6 (R = 0.33, P <0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = -0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.

KW - Adiponectin

KW - Pro-inflammatory cytokines

KW - Young diabetes

UR - http://www.scopus.com/inward/record.url?scp=79960229697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960229697&partnerID=8YFLogxK

U2 - 10.1007/s00592-009-0171-y

DO - 10.1007/s00592-009-0171-y

M3 - Article

C2 - 20058158

AN - SCOPUS:79960229697

VL - 48

SP - 113

EP - 119

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 2

ER -