Circulating intercellular adhesion molecule-1 (ICAM-1) in patients with hepatolithiasis

Shyr Ming Sheen-Chen, Hock Liew Eng, Yu Fan Cheng, Fong Fu Chou, Wei Jen Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We evaluated the role of circulating intercellular adhesion molecule-1 in the pathogenesis of hepatolithiasis. From December 1994 to May 1995, 40 patients with hepatolithiasis were included. All the patients met the following criteria: (1) presence of hepatolithiasis, (2) no obvious clinical evidence of an associated intrahepatic cholangiocarcinoma, (3) no clinical manifestation of cholangitis for at least 72 hr, (4) no immunomodulatory agents in the last three weeks, and (5) no blood transfusion in the last three weeks. Venous blood samples were collected both before surgery and at least three months after complete clearance of the stones, and the serum concentrations of circulating intercellular adhesion molecule-1 were measured with a sandwich enzyme immunoassay method. Fifteen healthy subjects were used as a control group. Bile specimens routinely obtained during surgery were cultured for aerobes and anaerobes. The x-ray films of cholangiography were all reviewed in detail. The mean value (834 ± 128 ng/ml) of circulating intercellular adhesion molecule-1 (ICAM-1) in the patient group before surgery was significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). The mean value (677 ± 139 ng/ml) of circulating ICAM-1 in the patient group at least three months after complete clearance of the stones was significantly lower than that (834 ± 128 ng/ml) of the patients before surgery (P < 0.01), but this mean value (677 ± 139 ng/ml) was still significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). Bacteria was present in the bile of all patients. The total number of bacterial species was 135, and there were an average of 3.4 bacterial species cultured per patient. Intrahepatic stricture was demonstrated in cholangiography in 33 patients (82.5%). In addition to the high incidence of intrahepatic bile duct strictures and bile infection, a significant elevation in circulating intercellular adhesion molecule-1 (sICAM-1) was shown in patients with hepatolithiasis. Our preliminary results seem to be promising and the real role of sICAM-1 deserves further investigation and elucidation.

Original languageEnglish
Pages (from-to)1682-1686
Number of pages5
JournalDigestive Diseases and Sciences
Volume41
Issue number8
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

Intercellular Adhesion Molecule-1
Bile
Cholangiography
Control Groups
Pathologic Constriction
Intrahepatic Bile Ducts
Cholangitis
Cholangiocarcinoma
Motion Pictures
Immunoenzyme Techniques
Blood Transfusion
Healthy Volunteers
X-Rays
Bacteria
Incidence
Infection
Serum

Keywords

  • Hepatolithiasis
  • Intercellular adhesion molecule-1

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Circulating intercellular adhesion molecule-1 (ICAM-1) in patients with hepatolithiasis. / Sheen-Chen, Shyr Ming; Eng, Hock Liew; Cheng, Yu Fan; Chou, Fong Fu; Chen, Wei Jen.

In: Digestive Diseases and Sciences, Vol. 41, No. 8, 01.01.1996, p. 1682-1686.

Research output: Contribution to journalArticle

Sheen-Chen, Shyr Ming ; Eng, Hock Liew ; Cheng, Yu Fan ; Chou, Fong Fu ; Chen, Wei Jen. / Circulating intercellular adhesion molecule-1 (ICAM-1) in patients with hepatolithiasis. In: Digestive Diseases and Sciences. 1996 ; Vol. 41, No. 8. pp. 1682-1686.
@article{067aaa8ae5ed433fb1e8269c961793cd,
title = "Circulating intercellular adhesion molecule-1 (ICAM-1) in patients with hepatolithiasis",
abstract = "We evaluated the role of circulating intercellular adhesion molecule-1 in the pathogenesis of hepatolithiasis. From December 1994 to May 1995, 40 patients with hepatolithiasis were included. All the patients met the following criteria: (1) presence of hepatolithiasis, (2) no obvious clinical evidence of an associated intrahepatic cholangiocarcinoma, (3) no clinical manifestation of cholangitis for at least 72 hr, (4) no immunomodulatory agents in the last three weeks, and (5) no blood transfusion in the last three weeks. Venous blood samples were collected both before surgery and at least three months after complete clearance of the stones, and the serum concentrations of circulating intercellular adhesion molecule-1 were measured with a sandwich enzyme immunoassay method. Fifteen healthy subjects were used as a control group. Bile specimens routinely obtained during surgery were cultured for aerobes and anaerobes. The x-ray films of cholangiography were all reviewed in detail. The mean value (834 ± 128 ng/ml) of circulating intercellular adhesion molecule-1 (ICAM-1) in the patient group before surgery was significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). The mean value (677 ± 139 ng/ml) of circulating ICAM-1 in the patient group at least three months after complete clearance of the stones was significantly lower than that (834 ± 128 ng/ml) of the patients before surgery (P < 0.01), but this mean value (677 ± 139 ng/ml) was still significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). Bacteria was present in the bile of all patients. The total number of bacterial species was 135, and there were an average of 3.4 bacterial species cultured per patient. Intrahepatic stricture was demonstrated in cholangiography in 33 patients (82.5{\%}). In addition to the high incidence of intrahepatic bile duct strictures and bile infection, a significant elevation in circulating intercellular adhesion molecule-1 (sICAM-1) was shown in patients with hepatolithiasis. Our preliminary results seem to be promising and the real role of sICAM-1 deserves further investigation and elucidation.",
keywords = "Hepatolithiasis, Intercellular adhesion molecule-1",
author = "Sheen-Chen, {Shyr Ming} and Eng, {Hock Liew} and Cheng, {Yu Fan} and Chou, {Fong Fu} and Chen, {Wei Jen}",
year = "1996",
month = "1",
day = "1",
doi = "10.1007/BF02087925",
language = "English",
volume = "41",
pages = "1682--1686",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "8",

}

TY - JOUR

T1 - Circulating intercellular adhesion molecule-1 (ICAM-1) in patients with hepatolithiasis

AU - Sheen-Chen, Shyr Ming

AU - Eng, Hock Liew

AU - Cheng, Yu Fan

AU - Chou, Fong Fu

AU - Chen, Wei Jen

PY - 1996/1/1

Y1 - 1996/1/1

N2 - We evaluated the role of circulating intercellular adhesion molecule-1 in the pathogenesis of hepatolithiasis. From December 1994 to May 1995, 40 patients with hepatolithiasis were included. All the patients met the following criteria: (1) presence of hepatolithiasis, (2) no obvious clinical evidence of an associated intrahepatic cholangiocarcinoma, (3) no clinical manifestation of cholangitis for at least 72 hr, (4) no immunomodulatory agents in the last three weeks, and (5) no blood transfusion in the last three weeks. Venous blood samples were collected both before surgery and at least three months after complete clearance of the stones, and the serum concentrations of circulating intercellular adhesion molecule-1 were measured with a sandwich enzyme immunoassay method. Fifteen healthy subjects were used as a control group. Bile specimens routinely obtained during surgery were cultured for aerobes and anaerobes. The x-ray films of cholangiography were all reviewed in detail. The mean value (834 ± 128 ng/ml) of circulating intercellular adhesion molecule-1 (ICAM-1) in the patient group before surgery was significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). The mean value (677 ± 139 ng/ml) of circulating ICAM-1 in the patient group at least three months after complete clearance of the stones was significantly lower than that (834 ± 128 ng/ml) of the patients before surgery (P < 0.01), but this mean value (677 ± 139 ng/ml) was still significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). Bacteria was present in the bile of all patients. The total number of bacterial species was 135, and there were an average of 3.4 bacterial species cultured per patient. Intrahepatic stricture was demonstrated in cholangiography in 33 patients (82.5%). In addition to the high incidence of intrahepatic bile duct strictures and bile infection, a significant elevation in circulating intercellular adhesion molecule-1 (sICAM-1) was shown in patients with hepatolithiasis. Our preliminary results seem to be promising and the real role of sICAM-1 deserves further investigation and elucidation.

AB - We evaluated the role of circulating intercellular adhesion molecule-1 in the pathogenesis of hepatolithiasis. From December 1994 to May 1995, 40 patients with hepatolithiasis were included. All the patients met the following criteria: (1) presence of hepatolithiasis, (2) no obvious clinical evidence of an associated intrahepatic cholangiocarcinoma, (3) no clinical manifestation of cholangitis for at least 72 hr, (4) no immunomodulatory agents in the last three weeks, and (5) no blood transfusion in the last three weeks. Venous blood samples were collected both before surgery and at least three months after complete clearance of the stones, and the serum concentrations of circulating intercellular adhesion molecule-1 were measured with a sandwich enzyme immunoassay method. Fifteen healthy subjects were used as a control group. Bile specimens routinely obtained during surgery were cultured for aerobes and anaerobes. The x-ray films of cholangiography were all reviewed in detail. The mean value (834 ± 128 ng/ml) of circulating intercellular adhesion molecule-1 (ICAM-1) in the patient group before surgery was significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). The mean value (677 ± 139 ng/ml) of circulating ICAM-1 in the patient group at least three months after complete clearance of the stones was significantly lower than that (834 ± 128 ng/ml) of the patients before surgery (P < 0.01), but this mean value (677 ± 139 ng/ml) was still significantly higher than that (346 ± 68 ng/ml) of the control group (P < 0.01). Bacteria was present in the bile of all patients. The total number of bacterial species was 135, and there were an average of 3.4 bacterial species cultured per patient. Intrahepatic stricture was demonstrated in cholangiography in 33 patients (82.5%). In addition to the high incidence of intrahepatic bile duct strictures and bile infection, a significant elevation in circulating intercellular adhesion molecule-1 (sICAM-1) was shown in patients with hepatolithiasis. Our preliminary results seem to be promising and the real role of sICAM-1 deserves further investigation and elucidation.

KW - Hepatolithiasis

KW - Intercellular adhesion molecule-1

UR - http://www.scopus.com/inward/record.url?scp=0029820055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029820055&partnerID=8YFLogxK

U2 - 10.1007/BF02087925

DO - 10.1007/BF02087925

M3 - Article

C2 - 8769302

AN - SCOPUS:0029820055

VL - 41

SP - 1682

EP - 1686

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 8

ER -