Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome

Kou G. Shyu, Hang Chang, Cheng Chung Lin, Peiliang Kuan

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Abstract

To characterize the role of circulating intercellular adhesion molecule-1 (ICAM-1) and E-selectin in patients with acute coronary syndrome, serum levels of ICAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay (ELISA). Group 1 comprised 17 patients with acute myocardial infarction; group 2 included 17 patients with unstable angina; and group 3 included 19 control subjects. These 53 patients all had prolonged chest pain within 24 h and all underwent coronary angiography. Group 1 and 2 patients had significant coronary artery disease, while group 3 had normal coronary arteries. Blood samples were collected at the emergency department before antiplatelet agents were given. Serum levels of ICAM-1 were higher in group 1 and 2 (383±27 and 337±11 ng/mL, respectively) as compared with group 3 (282±18 ng/mL) (group 1 vs 3, p

Original languageEnglish
Pages (from-to)1627-1630
Number of pages4
JournalChest
Volume109
Issue number6
Publication statusPublished - 1996
Externally publishedYes

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Keywords

  • acute coronary syndrome
  • adhesion molecule
  • enzyme-linked immunosorbent assay

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Shyu, K. G., Chang, H., Lin, C. C., & Kuan, P. (1996). Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome. Chest, 109(6), 1627-1630.