Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents

Fone Ching Hsiao, Yuh Feng Lin, Po Shiuan Hsieh, Nain Feng Chu, Yi Shing Shieh, Chang Hsun Hsieh, Chien Hsing Lee, Yi Jen Hung

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Context: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted byimmunecells, endothelial cells, vascularsmoothmuscle cells, and adipocytes. Preclinical studies indicate that Gas6 and its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. Until now, little has been known about the clinical significance of the Gas6/TAM system in childhood obesity. Objectives: This study aimed to determine whether circulating Gas6 and soluble Axl (sAxl) levels are associated with adiposity, inflammation, and insulin resistance status among Taiwanese adolescents. Methods: Cross-sectional analyses using the data from the Taipei Children Heart Study-III were performed. A total of 832 adolescents (average age, 13.3 years) were included; they were divided into 3 groups: lean, overweight, and obese. Circulating Gas6 and sAxl levels, adiposity, inflammatory markers, and insulin resistance status were examined. Results: Levels of circulating Gas6 and sAxl were significantly higher in overweight and obese adolescents than in the lean group (both P <.05). Circulating Gas6 levels were significantly positively correlated with body mass index Z-score (P <.045), waist circumference (P <.001), waist to hip circumference ratio (P =.001), body fat mass (P =.02), serum high-sensitivity C-reactive protein (P =.005), and tumor necrosis factor-α levels (P =.039) among overweight and obese adolescents. The correlations remained significant after adjusting for age, gender, Tanner stage, smoking status, and drinking status. In addition, every 1 ng/mL increase in circulating Gas6 concentration corresponded to a 15% to 19% increase in the risk of developing insulin resistance among overweight and obese adolescents. Conclusions: Circulating Gas6 levels are strongly associated with adiposity, inflammation, and insulin resistance status among overweight and obese adolescents. The potential role of the Gas6/TAM system in the initiation of childhood obesity and obesity-associated complications deserves further attention.

Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number2
DOIs
Publication statusPublished - Feb 2013

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Adiposity
Insulin Resistance
Insulin
Inflammation
Growth
Pediatric Obesity
Obesity
growth arrest-specific protein 6
Waist-Hip Ratio
Vitamin K
Endothelial cells
Waist Circumference
Adipocytes
C-Reactive Protein
Drinking
Adipose Tissue
Body Mass Index
Endothelial Cells
Tumor Necrosis Factor-alpha
Cross-Sectional Studies

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. / Hsiao, Fone Ching; Lin, Yuh Feng; Hsieh, Po Shiuan; Chu, Nain Feng; Shieh, Yi Shing; Hsieh, Chang Hsun; Lee, Chien Hsing; Hung, Yi Jen.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 02.2013.

Research output: Contribution to journalArticle

Hsiao, Fone Ching ; Lin, Yuh Feng ; Hsieh, Po Shiuan ; Chu, Nain Feng ; Shieh, Yi Shing ; Hsieh, Chang Hsun ; Lee, Chien Hsing ; Hung, Yi Jen. / Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 2.
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abstract = "Context: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted byimmunecells, endothelial cells, vascularsmoothmuscle cells, and adipocytes. Preclinical studies indicate that Gas6 and its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. Until now, little has been known about the clinical significance of the Gas6/TAM system in childhood obesity. Objectives: This study aimed to determine whether circulating Gas6 and soluble Axl (sAxl) levels are associated with adiposity, inflammation, and insulin resistance status among Taiwanese adolescents. Methods: Cross-sectional analyses using the data from the Taipei Children Heart Study-III were performed. A total of 832 adolescents (average age, 13.3 years) were included; they were divided into 3 groups: lean, overweight, and obese. Circulating Gas6 and sAxl levels, adiposity, inflammatory markers, and insulin resistance status were examined. Results: Levels of circulating Gas6 and sAxl were significantly higher in overweight and obese adolescents than in the lean group (both P <.05). Circulating Gas6 levels were significantly positively correlated with body mass index Z-score (P <.045), waist circumference (P <.001), waist to hip circumference ratio (P =.001), body fat mass (P =.02), serum high-sensitivity C-reactive protein (P =.005), and tumor necrosis factor-α levels (P =.039) among overweight and obese adolescents. The correlations remained significant after adjusting for age, gender, Tanner stage, smoking status, and drinking status. In addition, every 1 ng/mL increase in circulating Gas6 concentration corresponded to a 15{\%} to 19{\%} increase in the risk of developing insulin resistance among overweight and obese adolescents. Conclusions: Circulating Gas6 levels are strongly associated with adiposity, inflammation, and insulin resistance status among overweight and obese adolescents. The potential role of the Gas6/TAM system in the initiation of childhood obesity and obesity-associated complications deserves further attention.",
author = "Hsiao, {Fone Ching} and Lin, {Yuh Feng} and Hsieh, {Po Shiuan} and Chu, {Nain Feng} and Shieh, {Yi Shing} and Hsieh, {Chang Hsun} and Lee, {Chien Hsing} and Hung, {Yi Jen}",
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T1 - Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents

AU - Hsiao, Fone Ching

AU - Lin, Yuh Feng

AU - Hsieh, Po Shiuan

AU - Chu, Nain Feng

AU - Shieh, Yi Shing

AU - Hsieh, Chang Hsun

AU - Lee, Chien Hsing

AU - Hung, Yi Jen

PY - 2013/2

Y1 - 2013/2

N2 - Context: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted byimmunecells, endothelial cells, vascularsmoothmuscle cells, and adipocytes. Preclinical studies indicate that Gas6 and its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. Until now, little has been known about the clinical significance of the Gas6/TAM system in childhood obesity. Objectives: This study aimed to determine whether circulating Gas6 and soluble Axl (sAxl) levels are associated with adiposity, inflammation, and insulin resistance status among Taiwanese adolescents. Methods: Cross-sectional analyses using the data from the Taipei Children Heart Study-III were performed. A total of 832 adolescents (average age, 13.3 years) were included; they were divided into 3 groups: lean, overweight, and obese. Circulating Gas6 and sAxl levels, adiposity, inflammatory markers, and insulin resistance status were examined. Results: Levels of circulating Gas6 and sAxl were significantly higher in overweight and obese adolescents than in the lean group (both P <.05). Circulating Gas6 levels were significantly positively correlated with body mass index Z-score (P <.045), waist circumference (P <.001), waist to hip circumference ratio (P =.001), body fat mass (P =.02), serum high-sensitivity C-reactive protein (P =.005), and tumor necrosis factor-α levels (P =.039) among overweight and obese adolescents. The correlations remained significant after adjusting for age, gender, Tanner stage, smoking status, and drinking status. In addition, every 1 ng/mL increase in circulating Gas6 concentration corresponded to a 15% to 19% increase in the risk of developing insulin resistance among overweight and obese adolescents. Conclusions: Circulating Gas6 levels are strongly associated with adiposity, inflammation, and insulin resistance status among overweight and obese adolescents. The potential role of the Gas6/TAM system in the initiation of childhood obesity and obesity-associated complications deserves further attention.

AB - Context: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted byimmunecells, endothelial cells, vascularsmoothmuscle cells, and adipocytes. Preclinical studies indicate that Gas6 and its receptors of the TAM (Tyro-3, Axl, Mer) family may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. Until now, little has been known about the clinical significance of the Gas6/TAM system in childhood obesity. Objectives: This study aimed to determine whether circulating Gas6 and soluble Axl (sAxl) levels are associated with adiposity, inflammation, and insulin resistance status among Taiwanese adolescents. Methods: Cross-sectional analyses using the data from the Taipei Children Heart Study-III were performed. A total of 832 adolescents (average age, 13.3 years) were included; they were divided into 3 groups: lean, overweight, and obese. Circulating Gas6 and sAxl levels, adiposity, inflammatory markers, and insulin resistance status were examined. Results: Levels of circulating Gas6 and sAxl were significantly higher in overweight and obese adolescents than in the lean group (both P <.05). Circulating Gas6 levels were significantly positively correlated with body mass index Z-score (P <.045), waist circumference (P <.001), waist to hip circumference ratio (P =.001), body fat mass (P =.02), serum high-sensitivity C-reactive protein (P =.005), and tumor necrosis factor-α levels (P =.039) among overweight and obese adolescents. The correlations remained significant after adjusting for age, gender, Tanner stage, smoking status, and drinking status. In addition, every 1 ng/mL increase in circulating Gas6 concentration corresponded to a 15% to 19% increase in the risk of developing insulin resistance among overweight and obese adolescents. Conclusions: Circulating Gas6 levels are strongly associated with adiposity, inflammation, and insulin resistance status among overweight and obese adolescents. The potential role of the Gas6/TAM system in the initiation of childhood obesity and obesity-associated complications deserves further attention.

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