Circulating angiotensin-converting enzyme, von Willebrand factor antigen and thrombomodulin in exertional heat stroke

S. D. Shieh, J. C. Shiang, Y. F. Lin, W. Y. Shiao, J. Y. Wang

Research output: Contribution to journalArticle

25 Citations (Scopus)


1. Military recruits frequently succumb to exertional heat stroke during intensive training. Since widespread endothelial injury is often associated with exertional heat stroke, the relationship between changes in three circulating endothelial cell markers (angiotensin-converting enzyme, von Willebrand factor antigen and thrombomodulin) and exertional heat stroke was studied. 2. Twelve recruits who had succumbed to exertional heat stroke during basic physical training (5000 m running) were included in the study. Another 10 age-matched healthy subjects who had gone through the same physical training regimen were selected as controls. 3. Blood was withdrawn on admission and on discharge for analyses of angiotensin-converting enzyme, von Willebrand factor antigen and thrombomodulin. Other physiological parameters and biochemical analyses reflecting renal and liver functions were also recorded. 4. Our results indicated that these subjects with exertional heat stroke exhibited impaired liver function as revealed by the significant elevation of both serum glutamic oxaloacetic transaminase (P-1ml-1, P

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalClinical Science
Issue number3
Publication statusPublished - 1995
Externally publishedYes



  • Angiotensin-converting enzyme
  • Exertional heat stroke
  • Thrombomodulin
  • von Willebrand factor antigen

ASJC Scopus subject areas

  • Medicine(all)

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