Circadian variation of tacrolimus disposition in liver allograft recipients

David I. Min, Hsiang Yin Chen, Alfredo Fabrega, Ferdinand O. Ukah, You Min Wu, Claudia Corwin, M. Kay Ashton, Maureen Martin

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

The aim of this study was to characterize the circadian variation of oral tacrolimus disposition in 8 stable liver allograft recipients. In the steady state, a total of 23 blood samples was taken before and after tacrolimus administration during a 24-hr period and the pharmacokinetic parameters were compared. The area under the curve (AUC) of tacrolimus after the morning dose was significantly larger than after the evening dose (211±43 ng · hr/ml [morning] vs. 179±45 ng · hr/ml [evening], P=0.02). The time to peak (Tmax) was significantly shorter after the morning dose than after the evening dose (1.6±0.7 hr [morning] vs. 2.9±0.6 hr [evening], P=0.002). The peak (Cmax) was significantly higher after the morning dose than after the evening dose (32.2±10.2 ng/ml [morning] vs. 19.1±4.3 ng/ml [evening], P=0.003). However, the trough (Cmin) was not significantly different between the morning dose and the evening dose (13.1±3.9 ng/ml [morning] vs. 13.3±4.4 ng/ml [evening], P=0.4). This study demonstrated that tacrolimus disposition in liver transplant patients was determined by administration time.

Original languageEnglish
Pages (from-to)1190-1192
Number of pages3
JournalTransplantation
Volume62
Issue number8
DOIs
Publication statusPublished - Oct 27 1996
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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