Circadian rhythm in the Ca2+-inhibitable adenylyl cyclase activity of the rat striatum

Yijuang Chern, Eminy H Y Lee, Hsing Lin Lai, Hai Long Wang, Yi Chao Lee, Yung Hao Ching

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10 Citations (Scopus)

Abstract

In the present study, we demonstrate that the Ca2+-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca2+-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca2+-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalFEBS Letters
Volume385
Issue number3
DOIs
Publication statusPublished - May 6 1996
Externally publishedYes

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Keywords

  • Adenosine
  • Adenylyl cyclase
  • Circadian rhythm
  • Locomotor activity
  • Striatum

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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