Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Wen Chang Chang, Shoshi Fukuda, Hsin Hsiung Tai

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

Original languageEnglish
Pages (from-to)499-505
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume115
Issue number2
DOIs
Publication statusPublished - Sep 15 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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