Cigarette Smoking Aggravates the Activity of Periodontal Disease by Disrupting Redox Homeostasis- An Observational Study

Chia Huang Chang, Ming Lun Han, Nai Chia Teng, Chang Yu Lee, Wan Ting Huang, Che Tong Lin, Yung Kai Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to evaluate the associations between cigarette use and five salivary oxidative stress biomarkers, copper-zinc superoxide dismutase (Cu/Zn SOD), manganese superoxide dismutase (MnSOD), catalase, thioredoxin-1 (TRX1), and peroxiredoxin-2 (PRX2), to assess the effectiveness of non-surgical periodontal therapy. Materials and Methods: This is an observational study,167 patients diagnosed with periodontitis were recruited. Both saliva samples and clinical measurements (plaque index (PI), bleeding on probing (BOP), and pocket depth (PD)) were taken at baseline and after completing non-surgical periodontal therapy. The Levels of salivary biomarkers were determined using a MILLIPLEX® MAP Human Oxidative Stress Magnetic Bead Panel kit. The overall reductions in PI and BOP were 31.56% and 42.16%, respectively. BOP reduction after treatment in female or male non-smokers was significantly higher than in male former smokers (p < 0.05). After completing non-surgical periodontal therapy, Cu/ZnSOD, MnSOD, catalase, and Prx2 significantly decreased. There was a significant interaction between smoking status and ΔCu/ZnSOD on PI and a significant interaction between smoking status and ΔCatalase on BOP. Conclusions: Cigarette smoking interferes with redox homeostasis in the body, alters antioxidants levels, and influences the periodontal disease activity.

Original languageEnglish
Article number11055
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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Periodontal Diseases
Oxidation-Reduction
Observational Studies
Homeostasis
Smoking
Catalase
Hemorrhage
Superoxide Dismutase
Oxidative Stress
Biomarkers
Peroxiredoxins
Thioredoxins
Periodontitis
Therapeutics
Saliva
Tobacco Products
Zinc
Copper
Antioxidants

ASJC Scopus subject areas

  • General

Cite this

Cigarette Smoking Aggravates the Activity of Periodontal Disease by Disrupting Redox Homeostasis- An Observational Study. / Chang, Chia Huang; Han, Ming Lun; Teng, Nai Chia; Lee, Chang Yu; Huang, Wan Ting; Lin, Che Tong; Huang, Yung Kai.

In: Scientific Reports, Vol. 8, No. 1, 11055, 01.12.2018.

Research output: Contribution to journalArticle

Chang, Chia Huang ; Han, Ming Lun ; Teng, Nai Chia ; Lee, Chang Yu ; Huang, Wan Ting ; Lin, Che Tong ; Huang, Yung Kai. / Cigarette Smoking Aggravates the Activity of Periodontal Disease by Disrupting Redox Homeostasis- An Observational Study. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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