CIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

Chi Long Chen, Chun Yi Chiang, Kuang Wen Liao, Shu Yi Ho, Yi Fang Chang, Ken Hong Lim, Ruey Kuen Hsieh, Yu Ling Lin, Ying Wen Su

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods: Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0-3) and statistical association with clinical-pathological factors was determined. Results: High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion: High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical-pathologic factors.

Original languageEnglish
JournalInternational Journal of Gerontology
DOIs
Publication statusPublished - 2017

Fingerprint

Survival
Inhibitor of Apoptosis Proteins
Multivariate Analysis
Apoptosis
Staining and Labeling
Carcinoma, squamous cell of head and neck

Keywords

  • CIAP-2
  • Squamous cell carcinoma of head and neck

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

CIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck. / Chen, Chi Long; Chiang, Chun Yi; Liao, Kuang Wen; Ho, Shu Yi; Chang, Yi Fang; Lim, Ken Hong; Hsieh, Ruey Kuen; Lin, Yu Ling; Su, Ying Wen.

In: International Journal of Gerontology, 2017.

Research output: Contribution to journalArticle

Chen, Chi Long ; Chiang, Chun Yi ; Liao, Kuang Wen ; Ho, Shu Yi ; Chang, Yi Fang ; Lim, Ken Hong ; Hsieh, Ruey Kuen ; Lin, Yu Ling ; Su, Ying Wen. / CIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck. In: International Journal of Gerontology. 2017.
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AU - Chen, Chi Long

AU - Chiang, Chun Yi

AU - Liao, Kuang Wen

AU - Ho, Shu Yi

AU - Chang, Yi Fang

AU - Lim, Ken Hong

AU - Hsieh, Ruey Kuen

AU - Lin, Yu Ling

AU - Su, Ying Wen

PY - 2017

Y1 - 2017

N2 - Background: Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods: Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0-3) and statistical association with clinical-pathological factors was determined. Results: High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion: High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical-pathologic factors.

AB - Background: Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods: Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0-3) and statistical association with clinical-pathological factors was determined. Results: High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion: High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical-pathologic factors.

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KW - Squamous cell carcinoma of head and neck

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