Abstract
Rationale and objective: Whether monoamine oxidase inhibitors (MAOIs) can be used to suppress the reinforcing effect of cocaine remains unknown. This study was undertaken to examine effects of a long-term dosing regimen with selective MAOIs on cocaine and food reward. Materials and methods: Since single dose of clorgyline (2 mg/kg), deprenyl (1 mg/kg), and pargyline (10 mg/kg) did not acutely affect mouse locomotor activity, these doses were chosen to treat the male C57BL/6j mice on a daily basis. Results: Fourteen consecutive days of pretreatments with clorgyline, deprenyl, or pargyline (one injection per day) did not affect natural reward-supported operant behavior, since acquisition of the lever pressing responses for food pellets under an FR-1 protocol did not differ among these drug- and saline-treated mice. Likewise, 24 consecutive days of pretreatments with clorgyline did not alter acquisition of the cocaine (0.3 mg/kg per infusion)-supported operant responses under an FR-1 protocol. In contrast, 24 days of pretreatments with deprenyl and pargyline abolished the cocaine-supported operant responses under a similar protocol. Twenty-four days of clorgyline treatment enhanced serotonin contents in striatum, nucleus accumbens, and frontal cortex. Frontal cortical 3,4-dihydroxyphenylacetic acid and 5-hydroxyindoleacidic acid concentrations were decreased following 24 days of pretreatments with deprenyl and pargyline. These changes were not evident in mice pretreated with clorgyline. Conclusions: We suggest that long-term treatments with MAO-B inhibitors may decrease cocaine-supported operant responses in cocaine-naïve mice by selectively decreasing frontal cortical metabolism of dopamine and serotonin.
| Original language | English |
|---|---|
| Pages (from-to) | 141-149 |
| Number of pages | 9 |
| Journal | Psychopharmacology |
| Volume | 205 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2009 |
| Externally published | Yes |
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Keywords
- Cocaine
- Deprenyl
- MAO
- Pargyline
- Self administration
ASJC Scopus subject areas
- Pharmacology
Cite this
Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice. / Ho, Ming Che; Cherng, Chianfang G.; Tsai, Yen Ping N; Chiang, Chih Yuan; Chuang, Jia Ying; Kao, Shu Fang; Yu, Lung.
In: Psychopharmacology, Vol. 205, No. 1, 07.2009, p. 141-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice
AU - Ho, Ming Che
AU - Cherng, Chianfang G.
AU - Tsai, Yen Ping N
AU - Chiang, Chih Yuan
AU - Chuang, Jia Ying
AU - Kao, Shu Fang
AU - Yu, Lung
PY - 2009/7
Y1 - 2009/7
N2 - Rationale and objective: Whether monoamine oxidase inhibitors (MAOIs) can be used to suppress the reinforcing effect of cocaine remains unknown. This study was undertaken to examine effects of a long-term dosing regimen with selective MAOIs on cocaine and food reward. Materials and methods: Since single dose of clorgyline (2 mg/kg), deprenyl (1 mg/kg), and pargyline (10 mg/kg) did not acutely affect mouse locomotor activity, these doses were chosen to treat the male C57BL/6j mice on a daily basis. Results: Fourteen consecutive days of pretreatments with clorgyline, deprenyl, or pargyline (one injection per day) did not affect natural reward-supported operant behavior, since acquisition of the lever pressing responses for food pellets under an FR-1 protocol did not differ among these drug- and saline-treated mice. Likewise, 24 consecutive days of pretreatments with clorgyline did not alter acquisition of the cocaine (0.3 mg/kg per infusion)-supported operant responses under an FR-1 protocol. In contrast, 24 days of pretreatments with deprenyl and pargyline abolished the cocaine-supported operant responses under a similar protocol. Twenty-four days of clorgyline treatment enhanced serotonin contents in striatum, nucleus accumbens, and frontal cortex. Frontal cortical 3,4-dihydroxyphenylacetic acid and 5-hydroxyindoleacidic acid concentrations were decreased following 24 days of pretreatments with deprenyl and pargyline. These changes were not evident in mice pretreated with clorgyline. Conclusions: We suggest that long-term treatments with MAO-B inhibitors may decrease cocaine-supported operant responses in cocaine-naïve mice by selectively decreasing frontal cortical metabolism of dopamine and serotonin.
AB - Rationale and objective: Whether monoamine oxidase inhibitors (MAOIs) can be used to suppress the reinforcing effect of cocaine remains unknown. This study was undertaken to examine effects of a long-term dosing regimen with selective MAOIs on cocaine and food reward. Materials and methods: Since single dose of clorgyline (2 mg/kg), deprenyl (1 mg/kg), and pargyline (10 mg/kg) did not acutely affect mouse locomotor activity, these doses were chosen to treat the male C57BL/6j mice on a daily basis. Results: Fourteen consecutive days of pretreatments with clorgyline, deprenyl, or pargyline (one injection per day) did not affect natural reward-supported operant behavior, since acquisition of the lever pressing responses for food pellets under an FR-1 protocol did not differ among these drug- and saline-treated mice. Likewise, 24 consecutive days of pretreatments with clorgyline did not alter acquisition of the cocaine (0.3 mg/kg per infusion)-supported operant responses under an FR-1 protocol. In contrast, 24 days of pretreatments with deprenyl and pargyline abolished the cocaine-supported operant responses under a similar protocol. Twenty-four days of clorgyline treatment enhanced serotonin contents in striatum, nucleus accumbens, and frontal cortex. Frontal cortical 3,4-dihydroxyphenylacetic acid and 5-hydroxyindoleacidic acid concentrations were decreased following 24 days of pretreatments with deprenyl and pargyline. These changes were not evident in mice pretreated with clorgyline. Conclusions: We suggest that long-term treatments with MAO-B inhibitors may decrease cocaine-supported operant responses in cocaine-naïve mice by selectively decreasing frontal cortical metabolism of dopamine and serotonin.
KW - Cocaine
KW - Deprenyl
KW - MAO
KW - Pargyline
KW - Self administration
UR - http://www.scopus.com/inward/record.url?scp=67649440684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649440684&partnerID=8YFLogxK
U2 - 10.1007/s00213-009-1524-5
DO - 10.1007/s00213-009-1524-5
M3 - Article
C2 - 19343328
AN - SCOPUS:67649440684
VL - 205
SP - 141
EP - 149
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -