Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture

A Nationwide Population-Based Cohort Study

Shih Wei Huang, Wei Te Wang, Lin Chuan Chou, Hung Chou Chen, Tsan Hon Liou, Hui Wen Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hip fractures can lead to functional disability and high mortality rates among elderly patients. The aim of this study was to investigate whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture. A retrospective population-based 4-year cohort study was conducted using case-control matched analysis of data from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). Patients with a diagnosis of COPD between January 1, 2004 and December 31, 2007 were enrolled. A 2-stage approach and data from the National Health Interview Survey 2005 were applied to adjust for missing confounders in the LHID2005 cohort. Hazard ratios (HRs) and adjusted HRs were estimated hip fracture risk for the COPD. We enrolled 16,239 patients in the COPD cohort and 48,747 (1:3) patients in non-COPD cohort. The hip fracture incidences were 649 per 100,000 person-years in the study cohort and 369 per 100,000 person-years in non-COPD cohort. The hip fracture HR during the follow-up period was 1.78 (P <0.001) and the adjusted hip fracture HR was 1.57 (P <0.001) after adjustment for covariates by using the 2-stage approach method. Patients with COPD were at hip fracture risk and fracture-prevention strategies are essential for better quality of care.

Original languageEnglish
Article number23360
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Mar 18 2016

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Hip Fractures
Chronic Obstructive Pulmonary Disease
Cohort Studies
Population
Obstructive Lung Diseases
Health Insurance
Databases
Quality of Health Care
Health Surveys
Taiwan
Interviews
Mortality
Incidence

ASJC Scopus subject areas

  • General

Cite this

Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture : A Nationwide Population-Based Cohort Study. / Huang, Shih Wei; Wang, Wei Te; Chou, Lin Chuan; Chen, Hung Chou; Liou, Tsan Hon; Lin, Hui Wen.

In: Scientific Reports, Vol. 6, 23360, 18.03.2016.

Research output: Contribution to journalArticle

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