Chronic obstructive pulmonary disease in stage i non-small cell lung cancer that underwent anatomic resection: The role of a recurrence promoter

Chih Hsi Kuo, Ching Yang Wu, Kang Yun Lee, Shu Min Lin, Fu Tsai Chung, Yu Lun Lo, Chien Ying Liu, Te Chih Hsiung, Cheng Ta Yang, Yi Cheng Wu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Despite the use of anatomic resection, the post-surgical recurrence rate remains high in early-stage non-small cell lung cancer (NSCLC). Chronic inflammation plays a role in the mechanism that promotes tumor initiation. This study aimed to investigate the association between recurrence outcome and chronic inflammation-related co-morbidities in early-stage resected NSCLC. Methods: A review of medical records for recurrence outcome and co-morbidities, in terms of chronic obstructive pulmonary disease (COPD), DM, asthma and cardiovascular diseases, was performed with 181 patients with stage I NSCLC that underwent anatomic resection. Results: Subjects with T descriptors as T2a disease (49.5 vs. 28.0%, p <0.05) and the presence of COPD (42.4 vs. 20.7%, p <0.01) had a higher risk of tumor recurrence. Univariate analysis for recurrence-free survival showed T descriptor as T2a (21.5 months vs. NR, p <0.05) and the presence of COPD (20.5 months vs. NR, p <0.01) as significant factors predicting reduced survival. The presence of COPD (HR: 1.98; 95% CI, 1.29-.02, p <0.01) and T descriptor as T2a (HR: 2.01; 95% CI, 1.04-3.91, p <0.05) remain independent predictors of reduced recurrence-free survival in the Cox regression model. Patients with COPD were at higher risk of brain recurrence (OR: 7.88; 95% CI, 1.50-41.3, p <0.01). In contrast, patients without COPD showed a tendency toward recurrence in bone and liver (OR: 4.13; 95% CI, 1.08-15.8, p = 0.05). Conclusion: Subjects with COPD and T2a disease had a higher risk of recurrence. The role of COPD as a recurrence promoter merits further prospective investigation.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume11
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Anatomical resection
  • COPD
  • NSCLC
  • Recurrence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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