Chronic low-dose γ-radiation exposure and the alteration of the distribution of lymphocyte subpopulations in residents of radioactive buildings

W. P. Chang, J. S. Hwang, M. C. Hung, T. H. Hu, S. D. Lee, B. F. Hwang

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29 Citations (Scopus)

Abstract

Purpose: To elucidate the immunological change incurred in a human population by protracted γ-radiation exposure at home environment. Materials and methods: An examination on the CD3+, CD4+, CD8+ and HLA-DR+ lymphocyte subsets was arranged for 196 exposed subjects with mean excess cumulative dose of 169 mSv during 2-13 years of exposure. Another 55 close relatives of the exposed subjects were recruited as the non-exposed reference population. Results: The mean percentage of CD4+ T-lymphocytes, HLA-DR+ lymphocytes and the CD4+ /CD8+ ratios in the exposed subjects (35.5, 19.9 and 1.51 respectively) were significantly lower than those of reference individuals (38.0, 22.6 and 1.72; p=0.02, 0.003, and 0.03 respectively), while the CD8+ in total counts of the exposed was moderately increased above that of the reference populations (p=0.1). By ANOVA analysis, the percentages of CD4+ and HLA-DR+ subsets were significantly associated with radiation dose (p=0.0046, 0.003), while CD4+ /CD8+ ratios were moderately associated with dose (p=0.073). HLA-DR+ counts were significantly and positively associated with duration of relocation from radioactive apartments (p=0.029). Conclusions: Significant immunological effects were observed in those who had received chronic low-dose radiation exposure.

Original languageEnglish
Pages (from-to)1231-1239
Number of pages9
JournalInternational Journal of Radiation Biology
Volume75
Issue number10
DOIs
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

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