Chronic kidney disease stage is a modulator on the association between high-sensitivity c-reactive protein and coronary vasospastic angina

Heng Jung Hsu, Chiung Hui Yen, Kuang Hung Hsu, I. Wen Wu, Chin Chan Lee, Chiao Yin Sun, Chia Chi Chou, Chun Yu Chen, Shih Ying Yang, Chi Jen Tsai, Mai Szu Wu, Ming Jui Hung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1-3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD.

Original languageEnglish
Article number852507
JournalScientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Coronary Vasospasm
Chronic Renal Insufficiency
Modulators
Blood
blood
protein
Monocytes
Proteins
hemoglobin
Regression analysis
Logistics
serum
logistics
Creatinine
Blood Cell Count
regression analysis
Hemoglobins
Angina Pectoris
Leukocyte Count
Catheterization

ASJC Scopus subject areas

  • Environmental Science(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chronic kidney disease stage is a modulator on the association between high-sensitivity c-reactive protein and coronary vasospastic angina. / Hsu, Heng Jung; Yen, Chiung Hui; Hsu, Kuang Hung; Wu, I. Wen; Lee, Chin Chan; Sun, Chiao Yin; Chou, Chia Chi; Chen, Chun Yu; Yang, Shih Ying; Tsai, Chi Jen; Wu, Mai Szu; Hung, Ming Jui.

In: Scientific World Journal, Vol. 2014, 852507, 2014.

Research output: Contribution to journalArticle

Hsu, Heng Jung ; Yen, Chiung Hui ; Hsu, Kuang Hung ; Wu, I. Wen ; Lee, Chin Chan ; Sun, Chiao Yin ; Chou, Chia Chi ; Chen, Chun Yu ; Yang, Shih Ying ; Tsai, Chi Jen ; Wu, Mai Szu ; Hung, Ming Jui. / Chronic kidney disease stage is a modulator on the association between high-sensitivity c-reactive protein and coronary vasospastic angina. In: Scientific World Journal. 2014 ; Vol. 2014.
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abstract = "The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1-3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD.",
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AU - Yen, Chiung Hui

AU - Hsu, Kuang Hung

AU - Wu, I. Wen

AU - Lee, Chin Chan

AU - Sun, Chiao Yin

AU - Chou, Chia Chi

AU - Chen, Chun Yu

AU - Yang, Shih Ying

AU - Tsai, Chi Jen

AU - Wu, Mai Szu

AU - Hung, Ming Jui

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