Chronic kidney disease, but not diabetes, can predict 30-day outcomes in patients with ST-elevation myocardial infarction after primary percutaneous coronary intervention: A single-center experience

Cheng Chung Hung, Wei Chun Huang, Kuan Rau Chiou, Chin Chang Cheng, Feng Yu Kuo, Jin Shiou Yang, Ko Long Lin, Cheng Hung Chiang, Shin Hung Hsiao, Chi Cheng Lai, Tzu Wen Lin, Guang Yuan Mar, Chuen Wang Chiou, Chun Peng Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Patients with acute coronary syndrome and impaired renal function have been shown to have high mortality. However, there is scarce literature to date addressing the impact of diabetes mellitus (DM) and renal function on clinical outcomes of ST elevation myocardial infarction (STEMI) in Taiwan. Method: This study enrolled 512 STEMI patients who received primary percutaneous coronary intervention. Patients were divided into 4 groups including group 1: patients without DM or CKD (nDM-nCKD); group 2: patients with DM but without CKD (DM-nCKD); group 3: patients with CKD but without DM (nDM-CKD); group 4: patients with DM and CKD (DM-CKD). Patients were also classified into four groups based on their estimated glomerular filtration rates (eGFR): stage 1 (eGFR ≧ 90 ml/min/1.73 m2, n = 163), stage 2 (eGFR = 89-60 ml/min/1.73 m2, n = 171), stage 3 (eGFR = 59-30 ml/min/1.73 m2, n = 136), and stage 4 (eGFR < 30 ml/min/1.73 m2, n = 42). The complication rates, length of hospital stay, and 30-day outcomes were analyzed. Results: The patients in both the nDM-CKD group and DM-CKD group had higher incidences of hypotension, intra-aortic balloon counterpulsation use, and respiratory failure (p < 0.005). They had significantly longer hospital stay and 30-daymortality rates (p < 0.001). The patients with CKD stage 3 and 4 had longer hospital stay and higher 30-day mortality rates (p < 0.001). However, DM was not an independent factor on the length of hospital stay and 30-day mortality rates. Conclusions: STEMI patients with impaired renal function, but not DM, had significantly longer hospital stay and higher 30-day mortality rates.

Original languageEnglish
Pages (from-to)395-403
Number of pages9
JournalActa Cardiologica Sinica
Volume29
Issue number5
Publication statusPublished - Sep 1 2013
Externally publishedYes

Keywords

  • Chronic kidney disease
  • Diabetes mellitus
  • Mortality
  • Primary percutaneous coronary intervention
  • ST-segment elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Hung, C. C., Huang, W. C., Chiou, K. R., Cheng, C. C., Kuo, F. Y., Yang, J. S., Lin, K. L., Chiang, C. H., Hsiao, S. H., Lai, C. C., Lin, T. W., Mar, G. Y., Chiou, C. W., & Liu, C. P. (2013). Chronic kidney disease, but not diabetes, can predict 30-day outcomes in patients with ST-elevation myocardial infarction after primary percutaneous coronary intervention: A single-center experience. Acta Cardiologica Sinica, 29(5), 395-403.