Abstract

Background: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough.Methods: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Clinical data, treatment course and resolution of chronic cough were analysed. Specifically, gastro-oesophageal reflux (GERD), upper airway cough syndrome, asthma, apnoea-hypopnoea index and the impact of CPAP treatment on chronic cough were assessed.Results: A total of 131 patients were reviewed. The incidence of chronic cough in the OSA group was significantly higher than the non-OSA group (39/99 (39.4%) vs. 4/32 (12.5%), p = 0.005). Both GERD and apnoea-hypopnoea index were significantly associated with chronic cough in univariate analysis. After multivariate logistic regression, GERD was the only independent factor for chronic cough. Moreover, the resolution of chronic cough was more significant in the OSA patients with CPAP treatment compared with those not receiving CPAP treatment (12/18 (66.7%) vs. 2/21 (9.5%), p = 0.010).Conclusion: The incidence of chronic cough was significantly higher in the OSA patients. In addition, CPAP treatment significantly improved chronic cough. Therefore, OSA may be a contributory factor to chronic cough.

Original languageEnglish
Article number24
JournalCough
Volume9
Issue number1
DOIs
Publication statusPublished - Nov 5 2013

Fingerprint

Obstructive Sleep Apnea
Cough
Sleep
Lung
Continuous Positive Airway Pressure
Gastroesophageal Reflux
Apnea
Incidence
Therapeutics
Sleep Apnea Syndromes
Asthma
Logistic Models

Keywords

  • Chronic cough
  • Continuous positive airway pressure
  • Obstructive sleep apnoea

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pulmonary and Respiratory Medicine

Cite this

Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice. / Wang, Tsai Yu; Lo, Yu Lun; Liu, Wen Te; Lin, Shu Min; Lin, Ting Yu; Kuo, Chih Hsi; Chung, Fu Tsai; Chou, Pai Chien; Chang, Po Jui; Ni, Yung Lun; Ho, Shu Chuan; Lin, Horng Chyuan; Wang, Chun Hua; Yu, Chih Teng; Kuo, Han Pin.

In: Cough, Vol. 9, No. 1, 24, 05.11.2013.

Research output: Contribution to journalArticle

Wang, TY, Lo, YL, Liu, WT, Lin, SM, Lin, TY, Kuo, CH, Chung, FT, Chou, PC, Chang, PJ, Ni, YL, Ho, SC, Lin, HC, Wang, CH, Yu, CT & Kuo, HP 2013, 'Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice', Cough, vol. 9, no. 1, 24. https://doi.org/10.1186/1745-9974-9-24
Wang, Tsai Yu ; Lo, Yu Lun ; Liu, Wen Te ; Lin, Shu Min ; Lin, Ting Yu ; Kuo, Chih Hsi ; Chung, Fu Tsai ; Chou, Pai Chien ; Chang, Po Jui ; Ni, Yung Lun ; Ho, Shu Chuan ; Lin, Horng Chyuan ; Wang, Chun Hua ; Yu, Chih Teng ; Kuo, Han Pin. / Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice. In: Cough. 2013 ; Vol. 9, No. 1.
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abstract = "Background: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough.Methods: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Clinical data, treatment course and resolution of chronic cough were analysed. Specifically, gastro-oesophageal reflux (GERD), upper airway cough syndrome, asthma, apnoea-hypopnoea index and the impact of CPAP treatment on chronic cough were assessed.Results: A total of 131 patients were reviewed. The incidence of chronic cough in the OSA group was significantly higher than the non-OSA group (39/99 (39.4{\%}) vs. 4/32 (12.5{\%}), p = 0.005). Both GERD and apnoea-hypopnoea index were significantly associated with chronic cough in univariate analysis. After multivariate logistic regression, GERD was the only independent factor for chronic cough. Moreover, the resolution of chronic cough was more significant in the OSA patients with CPAP treatment compared with those not receiving CPAP treatment (12/18 (66.7{\%}) vs. 2/21 (9.5{\%}), p = 0.010).Conclusion: The incidence of chronic cough was significantly higher in the OSA patients. In addition, CPAP treatment significantly improved chronic cough. Therefore, OSA may be a contributory factor to chronic cough.",
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AU - Wang, Tsai Yu

AU - Lo, Yu Lun

AU - Liu, Wen Te

AU - Lin, Shu Min

AU - Lin, Ting Yu

AU - Kuo, Chih Hsi

AU - Chung, Fu Tsai

AU - Chou, Pai Chien

AU - Chang, Po Jui

AU - Ni, Yung Lun

AU - Ho, Shu Chuan

AU - Lin, Horng Chyuan

AU - Wang, Chun Hua

AU - Yu, Chih Teng

AU - Kuo, Han Pin

PY - 2013/11/5

Y1 - 2013/11/5

N2 - Background: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough.Methods: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Clinical data, treatment course and resolution of chronic cough were analysed. Specifically, gastro-oesophageal reflux (GERD), upper airway cough syndrome, asthma, apnoea-hypopnoea index and the impact of CPAP treatment on chronic cough were assessed.Results: A total of 131 patients were reviewed. The incidence of chronic cough in the OSA group was significantly higher than the non-OSA group (39/99 (39.4%) vs. 4/32 (12.5%), p = 0.005). Both GERD and apnoea-hypopnoea index were significantly associated with chronic cough in univariate analysis. After multivariate logistic regression, GERD was the only independent factor for chronic cough. Moreover, the resolution of chronic cough was more significant in the OSA patients with CPAP treatment compared with those not receiving CPAP treatment (12/18 (66.7%) vs. 2/21 (9.5%), p = 0.010).Conclusion: The incidence of chronic cough was significantly higher in the OSA patients. In addition, CPAP treatment significantly improved chronic cough. Therefore, OSA may be a contributory factor to chronic cough.

AB - Background: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough.Methods: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Clinical data, treatment course and resolution of chronic cough were analysed. Specifically, gastro-oesophageal reflux (GERD), upper airway cough syndrome, asthma, apnoea-hypopnoea index and the impact of CPAP treatment on chronic cough were assessed.Results: A total of 131 patients were reviewed. The incidence of chronic cough in the OSA group was significantly higher than the non-OSA group (39/99 (39.4%) vs. 4/32 (12.5%), p = 0.005). Both GERD and apnoea-hypopnoea index were significantly associated with chronic cough in univariate analysis. After multivariate logistic regression, GERD was the only independent factor for chronic cough. Moreover, the resolution of chronic cough was more significant in the OSA patients with CPAP treatment compared with those not receiving CPAP treatment (12/18 (66.7%) vs. 2/21 (9.5%), p = 0.010).Conclusion: The incidence of chronic cough was significantly higher in the OSA patients. In addition, CPAP treatment significantly improved chronic cough. Therefore, OSA may be a contributory factor to chronic cough.

KW - Chronic cough

KW - Continuous positive airway pressure

KW - Obstructive sleep apnoea

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