Chronic administration of octreotide ameliorates portal hypertension and portal hypertensive gastropathy in rats with cirrhosis

Che Chang Chan, Fa Yauh Lee, Sun Sang Wang, Full Young Chang, Han Chieh Lin, Hwai Jeng Lin, Chi Jen Chu, Shwu Ling Wu, Chun Ching Tai, Shou Dong Lee

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8 Citations (Scopus)

Abstract

1. Portal hypertension and hyperdynamic circulation have been postulated to play a role in the pathogenesis of portal hypertensive gastropathy. Administration of octreotide to portal hypertensive rats has been shown to reduce portal pressure and ameliorate hyperdynamic circulation. 2. This study investigated the effects of chronic administration of octreotide on systemic and portal haemodynamics and the development of portal hypertensive gastropathy in carbon tetrachloride-induced cirrhotic rats. 3. After 12 weeks of carbon tetrachloride induction, cirrhotic rats were randomly assigned to receive either placebo (5% dextrose in water) or octreotide (65 μg/kg in 5% dextrose in water) subcutaneously twice daily for 10 days. Haemodynamic studies with a thermodilution technique and gastric morphemetric analyses were performed at 10 days after treatment. 4. In cirrhotic rats, octreotide treatment induced a significant increase in systemic vascular resistance (2.7 ± 0.2 versus 3.4 ± 0.2 mmHg/ml·min-1·100 g-1, P <0.05) and decrease in portal pressure (12.5 ± 1.2 versus 9.9 ± 0.5 mmHg, P <0.05) compared with placebo-treated rats. In addition, octreotide treatment significantly reduced the mean cross-sectional area of gastric mucosal vessels (2290 ± 145 versus 1810 ± 101 μm2, P <0.05). 5. This study shows that chronic octreotide treatment ameliorates the development of portal hypertensive gastropathy in cirrhotic rats. The effect of octreotide on portal hypertensive gastropathy may, at least partly, be due to the alleviation of portal hypertension and hyperdynamic circulation.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalClinical Science
Volume94
Issue number4
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Cirrhosis
  • Octreotide
  • Portal hypertension
  • Portal hypertensive gastropathy

ASJC Scopus subject areas

  • Medicine(all)

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    Chan, C. C., Lee, F. Y., Wang, S. S., Chang, F. Y., Lin, H. C., Lin, H. J., Chu, C. J., Wu, S. L., Tai, C. C., & Lee, S. D. (1998). Chronic administration of octreotide ameliorates portal hypertension and portal hypertensive gastropathy in rats with cirrhosis. Clinical Science, 94(4), 367-371.