Chromium yeast supplementation improves fasting plasma glucose and LDL-cholesterol in streptozotocin-induced diabetic rats

Ming Hoang Lai, Ya Yen Chen, Hsing Hsien Cheng

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Chromium yeast supplementation has been studied for its ability to improve carbohydrate and lipid abnormalities. There have been some earlier literature-reported studies involving chromium supplementation amongst patients suffering diabetes, but the results would appear to be somewhat varied. Forty male Wistar rats (ten weeks old, 300 g in average body mass) were divided into one of four groups, namely (i) controls; (ii) controls treated with chromium yeast; (iii) diabetic controls; and (iv) diabetic rats treated with chromium yeast. In the present investigation, the effect of a four-week oral administration of chromium yeast (600 μg of Cr/kg body mass/day, by gavage) upon the glucose and lipid metabolism in streptozotocin (STZ)-induced diabetic rats was assessed. Supplemental Cr yeast decreased the fasting blood glucose amongst the STZ-diabetic rats. No significant difference was observed in plasma fructosamine levels of rats treated with chromium yeast compared to control rats. Supplemental Cr yeast did decrease the plasma low-density lipoprotein (LDL)-cholesterol level for the STZ-diabetic rats as compared to controls. We noted no significant effect of chromium supplementation upon plasma high-density lipoprotein (HDL)-cholesterol or triglycerides compared to controls. Treatment with chromium yeast significantly increased the blood and urine chromium levels for both the diabetic and normal rats compared to respective control groups. The results of these studies suggest that Cr yeast decreased the fasting blood glucose and LDL-cholesterol levels in STZ-induced diabetic rats. This raises the possibility that Cr yeast supplementation can be considered to improve carbohydrate and lipid metabolism amongst human patients featuring type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalInternational Journal for Vitamin and Nutrition Research
Volume76
Issue number6
DOIs
Publication statusPublished - Nov 2006

Fingerprint

streptozotocin
Chromium
Streptozocin
low density lipoprotein cholesterol
chromium
LDL Cholesterol
fasting
Fasting
Yeasts
yeasts
Glucose
glucose
rats
Lipid Metabolism
lipid metabolism
blood glucose
Blood Glucose
Fructosamine
Aptitude
Carbohydrate Metabolism

Keywords

  • Carbohydrate metabolism
  • Chromium yeast
  • Diabetes
  • Lipid metabolism
  • Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Chromium yeast supplementation improves fasting plasma glucose and LDL-cholesterol in streptozotocin-induced diabetic rats. / Lai, Ming Hoang; Chen, Ya Yen; Cheng, Hsing Hsien.

In: International Journal for Vitamin and Nutrition Research, Vol. 76, No. 6, 11.2006, p. 391-397.

Research output: Contribution to journalArticle

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