Chromatography in plasma fractionation: benefits and future trends

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

Industrial-scale chromatographic fractionation and purification methods have been used increasingly in the last few years for plasma fractionation. This has resulted in the development of a new generation of therapeutic plasma derivatives, especially coagulation factors, protease inhibitors and anticoagulants. Implementation and combination of ion-exchange, affinity and size-exclusion chromatography have allowed the development of new therapeutic products with improved purity and safety for treating congenital or acquired plasma protein deficiencies in patients. More recently, the benefit of chromatographic purification of plasma proteins in the removal of plasma-borne viruses has been revealed. Development of packing materials with improved characteristics for industrial applications, including higher capacity and rigidity, should further promote the use of chromatography as an essential plasma fractionation tool and confine more and more the traditional ethanol precipitation methods to the final processing stages used to recover albumin.

Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume664
Issue number1
DOIs
Publication statusPublished - Feb 3 1995
Externally publishedYes

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Fractionation
Chromatography
Plasmas
Purification
Blood Proteins
Blood Coagulation Factors
Size exclusion chromatography
Protease Inhibitors
Viruses
Rigidity
Anticoagulants
Industrial applications
Albumins
Ion exchange
Ethanol
Derivatives
Processing

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Chromatography in plasma fractionation : benefits and future trends. / Burnouf, T.

In: Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 664, No. 1, 03.02.1995, p. 3-15.

Research output: Contribution to journalReview article

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