Chromatographically purified vancomycin: Therapy of serious infections caused by Staphylococcus aureus and other gram-positive bacteria

L. S. Wang, C. Y. Liu, F. D. Wang, C. P. Fung, Z. H. Chiu, D. L. Cheng

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Abstract

Fourteen patients with serious infections caused by Staphylococcus aureus and other gram-positive bacteria were prospectively treated with chromatographically purified vancomycin in an open-label, nonrandomized study, between December 1986 and June 1987. Five patients were excluded from the evaluation of efficacy. Among the nine evaluable patients, cure was achieved in six patients - a success rate of 67%. One patient had a relapse of osteomyelitis, and cultures of draining pus were positive for oxacillin-resistant S aureus within three weeks after the discontinuation of vancomycin therapy. One patient failed to respond to vancomycin therapy for S aureus - induced endocarditis, meningitis, and osteomyelitis; in another patient, the treatment failed to reverse the course of S aureus septicemia. No serious drug toxicity, for example, nephrotoxicity, was encountered in any patient. One patient (7%) experienced mild ototoxicity. Four patients (29%) had mild phlebitis, two patients (14%) had a transiently positive Coombs' test, and one patient (7%) had a 'red neck syndrome' and 'pain and spasm syndrome'. Chromatographically purified vancomycin is an effective antibiotic in the treatment of serious infections caused by susceptible gram-positive bacteria. Some minor side effects of vancomycin may not be due to impurities in the preparation but rather to the vancomycin itself.

Original languageEnglish
Pages (from-to)574-584
Number of pages11
JournalClinical Therapeutics
Volume10
Issue number5
Publication statusPublished - 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Wang, L. S., Liu, C. Y., Wang, F. D., Fung, C. P., Chiu, Z. H., & Cheng, D. L. (1988). Chromatographically purified vancomycin: Therapy of serious infections caused by Staphylococcus aureus and other gram-positive bacteria. Clinical Therapeutics, 10(5), 574-584.