Chromaligner: A web server for chromatogram alignment

San Yuan Wang, Tsung Jung Ho, Ching Hua Kuo, Yufeng J. Tseng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Summary: Chromaligner is a tool for chromatogram alignment to align retention time for chromatographic methods coupled to spectrophotometers such as high performance liquid chromatography and capillary electrophoresis for metabolomics works. Chromaligner resolves peak shifts by a constrained chromatogram alignment. For a collection of chromatograms and a set of defined peaks, Chromaligner aligns the chromatograms on defined peaks using correlation warping (COW). Chromaligner is faster than the original COW algorithm by k2 times, where k is the number of defined peaks in a chromatogram. It also provides alignments based on known component peaks to reach the best results for further chemometric analysis.

Original languageEnglish
Article numberbtq337
Pages (from-to)2338-2339
Number of pages2
JournalBioinformatics
Volume26
Issue number18
DOIs
Publication statusPublished - Jun 23 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

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