Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients

I. Kuan Wang, Chung Hsiang Liu, Tzung Hai Yen, Jiann Shing Jeng, Shih Pin Hsu, Chih Hung Chen, Li Ming Lien, Ruey Tay Lin, An Chih Chen, Huey Juan Lin, Hsin Yi Chi, Ta Chang Lai, Yu Sun, Siu Pak Lee, Sheng Feng Sung, Po Lin Chen, Jiunn Tay Lee, Tsuey Ru Chiang, Shinn Kuang Lin, Chih Hsin MuoHenry Ma, Chi Pang Wen, Fung Chang Sung, Chung Y. Hsu, Chung Hsiang Liu, Chon Haw Tsai, Wei Shih Huang, Chung Ta Lu, Tzung Chang Tsai, Chun Hung Tseng, Kang Hsu Lin, Woei Cherng Shyn, Yu Wan Yang, Y. Liu, Der Yang Cho, Chun Chung Chen, Jiann Shing Jeng, Sung Chun Tang, Li Kai Tsai, Shin Joe Yeh, Shih Pin Hsu, Han Jung Chen, Cheng Sen Chang, Hung Chang Kuo, Lian Hui Lee, Huan Wen Tsui, Jung Chi Tsou, Yan Tang Wang, Yi Cheng Tai, Kun Chang Tsai, Y. W. Chen, K Lu, Po Chao Liliang, Yu Tun Tsai, Cheng Loong Liang, Kuo Wei Wang, Hao Kuang Wang, Jui Sheng Chen, Po-Yuan Chen, Cien Leong Chye, Wei Jie Tzeng, Pei Hua Wu, Chih Hung Chen, Pi Shan Sung, Han Chieh Hsieh, Hui Chen Su, Hou Chang Chiu, Li Ming Lien, Wei Hung Chen, Chyi-Huey Bai, Tzu Hsuan Huang, Chi Ieong Lau, Ya Ying Wu, Hsu Ling Yeh, Anna Chang, Ching Huang Lin, Cheng Chang Yen, Ruey Tay Lin, C. H. Chen, Gim Thean Khor, A. Ching Chao, Hsiu Fen Lin, Poyin Huang, Huey Juan Lin, Der Shin Ke, Chia Yu Chang, Poh Shiow Yeh, Kao Chang Lin, Tain Junn Cheng, Chih Ho Chou, Chun Ming Yang, Hsiu Chu Shen, An Chih Chen, Shih Jei Tsai, Tsong Ming Lu, Sheng Ling Kung, Mei Ju Lee, Hsi Hsien Chou, Hsin Yi Chi, Chou Hsiung Pan, Po Chi Chan, Min Hsien Hsu, Wei Lun Chang, Ya Ying Wu, Zhi Zang Huang, Hai Ming Shoung, Yi Chen Lo, Fu Hwa Wang, Ta Chang Lai, Jiu Haw Yin, C. J. Wang, Kai Chen Wang, Li Mei Chen, Jong Chyou Denq, Yu Sun, Chien Jung Lu, Cheng Huai Lin, Chieh Cheng Huang, Chang Hsiu Liu, Hoi Fong Chan, Jia-Ying Sung, Chin-I Chen, Lung Chan, Shu-Ping Chao, Chih-Shan Huang, Chaur-Jong Hu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We investigated the impact of serum cholesterol levels on 30-day mortality after ischemic stroke in dialysis patients. Methods: From the Taiwan Stroke Registry data, we identified 46,770 ischemic stroke cases, including 1101 dialysis patients and 45,669 nondialysis patients from 2006 to 2013. Results: Overall, the 30-day mortality was 1.46-fold greater in the dialysis group than in the nondialysis group (1.75 versus 1.20 per 1000 person-days). The mortality rates were 1.64, .62, 2.82, and 2.23 per 1000 person-days in dialysis patients with serum total cholesterol levels of <120 mg/dL, 120-159 mg/dL, 160-199 mg/dL, and ≥200 mg/dL, respectively. Compared to dialysis patients with serum total cholesterol levels of 120-159 mg/dL, the corresponding adjusted hazard ratios of mortality were 4.20 (95% confidence interval [CI] = 1.01-17.4), 8.06 (95% CI = 2.02-32.2), and 6.89 (95% CI = 1.59-29.8) for those with cholesterol levels of <120 mg/dL, 160-199 mg/dL, and ≥200 mg/dL, respectively. Conclusions: Dialysis patients with serum total cholesterol levels of ≥160 mg/dL or <120 mg/dL on admission are at an elevated hazard of 30-day mortality after ischemic stroke.

Original languageEnglish
Pages (from-to)1349-1356
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume26
Issue number6
DOIs
Publication statusPublished - 2017

Keywords

  • Cholesterol
  • Dialysis
  • Ischemic stroke, mortality
  • Prognosis

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Wang, I. K., Liu, C. H., Yen, T. H., Jeng, J. S., Hsu, S. P., Chen, C. H., Lien, L. M., Lin, R. T., Chen, A. C., Lin, H. J., Chi, H. Y., Lai, T. C., Sun, Y., Lee, S. P., Sung, S. F., Chen, P. L., Lee, J. T., Chiang, T. R., Lin, S. K., ... Hu, C-J. (2017). Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients. Journal of Stroke and Cerebrovascular Diseases, 26(6), 1349-1356. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.02.007