CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression

Shih Wei Wang; Shiow Lin Pan; Chieh Yu Peng; Der Yi Huang; An Chi Tsai; Ya Ling Chang; Jih Hwa Guh; Sheng Chu Kuo; Kuo Hsiung Lee; Che Ming Teng

doi:10.1016/j.canlet.2007.07.002

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression

Shih Wei Wang, Shiow Lin Pan, Chieh Yu Peng, Der Yi Huang, An Chi Tsai, Ya Ling Chang, Jih Hwa Guh, Sheng Chu Kuo, Kuo Hsiung Lee, Che Ming Teng

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion.

Original language	English
Pages (from-to)	87-96
Number of pages	10
Journal	Cancer Letters
Volume	257
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2007.07.002
Publication status	Published - Nov 8 2007
Externally published	Yes

Keywords

HGF
Hepatocellular carcinoma
Invasion
MMP-9

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2007.07.002

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Wang, S. W., Pan, S. L., Peng, C. Y., Huang, D. Y., Tsai, A. C., Chang, Y. L., Guh, J. H., Kuo, S. C., Lee, K. H., & Teng, C. M. (2007). CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression. Cancer Letters, 257(1), 87-96. https://doi.org/10.1016/j.canlet.2007.07.002

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title = "CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression",

abstract = "Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion.",

keywords = "HGF, Hepatocellular carcinoma, Invasion, MMP-9",

author = "Wang, {Shih Wei} and Pan, {Shiow Lin} and Peng, {Chieh Yu} and Huang, {Der Yi} and Tsai, {An Chi} and Chang, {Ya Ling} and Guh, {Jih Hwa} and Kuo, {Sheng Chu} and Lee, {Kuo Hsiung} and Teng, {Che Ming}",

note = "Funding Information: This work was supported by the National Science Council of the Republic of China (NSC 94-2811-B-002-017) awarded to C.-M. Teng and in part by grant from NIH CA17625 awarded to K.-H. Lee. ",

year = "2007",

month = nov,

day = "8",

doi = "10.1016/j.canlet.2007.07.002",

language = "English",

volume = "257",

pages = "87--96",

journal = "Cancer Letters",

issn = "0304-3835",

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TY - JOUR

T1 - CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression

AU - Wang, Shih Wei

AU - Pan, Shiow Lin

AU - Peng, Chieh Yu

AU - Huang, Der Yi

AU - Tsai, An Chi

AU - Chang, Ya Ling

AU - Guh, Jih Hwa

AU - Kuo, Sheng Chu

AU - Lee, Kuo Hsiung

AU - Teng, Che Ming

N1 - Funding Information: This work was supported by the National Science Council of the Republic of China (NSC 94-2811-B-002-017) awarded to C.-M. Teng and in part by grant from NIH CA17625 awarded to K.-H. Lee.

PY - 2007/11/8

Y1 - 2007/11/8

N2 - Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion.

AB - Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion.

KW - HGF

KW - Hepatocellular carcinoma

KW - Invasion

KW - MMP-9

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M3 - Article

C2 - 17689859

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SN - 0304-3835

VL - 257

SP - 87

EP - 96

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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