Chitosan-polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug. II. Effect of pH-dependent ionic crosslinking or interpolymer complex using tripolyphosphate or polyphosphate as reagent

Fwu Long Mi, Shin Shing Shyu, Tsung Bi Wong, Shiang Fang Jang, Sung Tao Lee, Kai Tai Lu

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105 Citations (Scopus)

Abstract

Chitosan gel beads were prepared using an in-liquid curing method by ionotropic crosslinking or interpolymer linkage with tripolyphosphate (TPP) or polyphosphate (PP). The ionic interaction of chitosan with TPP or PP is pH-dependent due to the transition of `ladder-loop' complex structures. Chitosan gel beads cured in a pH value lower than 6 of a TPP solution was a controlled homogeneous ionic-crosslinking reaction, whereas chitosan gel beads cured in a lower pH PP solution was a nonhomogeneous interpolymer complex reaction due to the mass-transfer resistance for the diffusion of macromolecular PP. According to the results of FTIR and EDS studies, it was suggested that significantly increasing the ionic-crosslinking density or interpolymer linkage of a chitosan-TPP or chitosan-PP complex could be achieved by transferring the pH value of curing agent, TPP or PP, from basic to acidic. The swelling behavior of various chitosan beads in acid medium appeared to depend on the ionic-crosslinking density or interpolymer linkage of the chitosan-TPP or chitosan-PP complex, which were deeply affected by the in-liquid curing mechanism of the chitosan gel beads. By the transition of the in-liquid curing mechanism, the swelling degree of chitosan-TPP or chitosan-PP beads was depressed and the disintegration of chitosan-TPP or chitosan-PP beads did not occur in strong acid. The drug-release patterns of the modified chitosan gel beads in simulated intestinal and gastric juices were sustained for 20 h. These results indicate that the sustained release of anti-cancer drugs could be achieved due to the variation of the reaction mechanism of a chitosan-polyelectrolyte pH-dependent ionic interaction.

Original languageEnglish
Pages (from-to)1093-1107
Number of pages15
JournalJournal of Applied Polymer Science
Volume74
Issue number5
DOIs
Publication statusPublished - 1999
Externally publishedYes

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Polyphosphates
Chitosan
Polyelectrolytes
Complexation
Crosslinking
Gels
Pharmaceutical Preparations
Curing
triphosphoric acid
Swelling
Liquids
Acids
Disintegration
Ladders

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

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title = "Chitosan-polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug. II. Effect of pH-dependent ionic crosslinking or interpolymer complex using tripolyphosphate or polyphosphate as reagent",
abstract = "Chitosan gel beads were prepared using an in-liquid curing method by ionotropic crosslinking or interpolymer linkage with tripolyphosphate (TPP) or polyphosphate (PP). The ionic interaction of chitosan with TPP or PP is pH-dependent due to the transition of `ladder-loop' complex structures. Chitosan gel beads cured in a pH value lower than 6 of a TPP solution was a controlled homogeneous ionic-crosslinking reaction, whereas chitosan gel beads cured in a lower pH PP solution was a nonhomogeneous interpolymer complex reaction due to the mass-transfer resistance for the diffusion of macromolecular PP. According to the results of FTIR and EDS studies, it was suggested that significantly increasing the ionic-crosslinking density or interpolymer linkage of a chitosan-TPP or chitosan-PP complex could be achieved by transferring the pH value of curing agent, TPP or PP, from basic to acidic. The swelling behavior of various chitosan beads in acid medium appeared to depend on the ionic-crosslinking density or interpolymer linkage of the chitosan-TPP or chitosan-PP complex, which were deeply affected by the in-liquid curing mechanism of the chitosan gel beads. By the transition of the in-liquid curing mechanism, the swelling degree of chitosan-TPP or chitosan-PP beads was depressed and the disintegration of chitosan-TPP or chitosan-PP beads did not occur in strong acid. The drug-release patterns of the modified chitosan gel beads in simulated intestinal and gastric juices were sustained for 20 h. These results indicate that the sustained release of anti-cancer drugs could be achieved due to the variation of the reaction mechanism of a chitosan-polyelectrolyte pH-dependent ionic interaction.",
author = "Mi, {Fwu Long} and Shyu, {Shin Shing} and Wong, {Tsung Bi} and Jang, {Shiang Fang} and Lee, {Sung Tao} and Lu, {Kai Tai}",
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AU - Mi, Fwu Long

AU - Shyu, Shin Shing

AU - Wong, Tsung Bi

AU - Jang, Shiang Fang

AU - Lee, Sung Tao

AU - Lu, Kai Tai

PY - 1999

Y1 - 1999

N2 - Chitosan gel beads were prepared using an in-liquid curing method by ionotropic crosslinking or interpolymer linkage with tripolyphosphate (TPP) or polyphosphate (PP). The ionic interaction of chitosan with TPP or PP is pH-dependent due to the transition of `ladder-loop' complex structures. Chitosan gel beads cured in a pH value lower than 6 of a TPP solution was a controlled homogeneous ionic-crosslinking reaction, whereas chitosan gel beads cured in a lower pH PP solution was a nonhomogeneous interpolymer complex reaction due to the mass-transfer resistance for the diffusion of macromolecular PP. According to the results of FTIR and EDS studies, it was suggested that significantly increasing the ionic-crosslinking density or interpolymer linkage of a chitosan-TPP or chitosan-PP complex could be achieved by transferring the pH value of curing agent, TPP or PP, from basic to acidic. The swelling behavior of various chitosan beads in acid medium appeared to depend on the ionic-crosslinking density or interpolymer linkage of the chitosan-TPP or chitosan-PP complex, which were deeply affected by the in-liquid curing mechanism of the chitosan gel beads. By the transition of the in-liquid curing mechanism, the swelling degree of chitosan-TPP or chitosan-PP beads was depressed and the disintegration of chitosan-TPP or chitosan-PP beads did not occur in strong acid. The drug-release patterns of the modified chitosan gel beads in simulated intestinal and gastric juices were sustained for 20 h. These results indicate that the sustained release of anti-cancer drugs could be achieved due to the variation of the reaction mechanism of a chitosan-polyelectrolyte pH-dependent ionic interaction.

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