Chitosan Microspheres: Modification of Polymeric Chem-Physical Properties of Spray-Dried Microspheres to Control the Release of Antibiotic Drug

Fwu Long Mi, Tsung Bi Wong, Shin Shing Shyu, Shon Foun Chang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved.

Original languageEnglish
Pages (from-to)747-759
Number of pages13
JournalJournal of Applied Polymer Science
Volume71
Issue number5
Publication statusPublished - Jan 31 1999
Externally publishedYes

ASJC Scopus subject areas

  • Polymers and Plastics

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