Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation

Kai-Chiang Yang; Zhi Qi; Feng Huei Lin; Chang Chin Wu; Shoichiro Sumi

doi:10.1007/978-3-642-12020-6-44

Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation

Kai-Chiang Yang, Zhi Qi, Feng Huei Lin, Chang Chin Wu, Shoichiro Sumi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.

Original language	English
Title of host publication	IFMBE Proceedings
Pages	179-181
Number of pages	3
Volume	27
DOIs	https://doi.org/10.1007/978-3-642-12020-6-44
Publication status	Published - 2010
Externally published	Yes
Event	3rd International Conference on the Development of Biomedical Engineering in Vietnam - Ho Chi Minh City, Viet Nam Duration: Jan 11 2010 → Jan 14 2010

Other

Other	3rd International Conference on the Development of Biomedical Engineering in Vietnam
Country/Territory	Viet Nam
City	Ho Chi Minh City
Period	1/11/10 → 1/14/10

Keywords

Chitosan hydrogel
Encapsulation
Immunoisolation
Type 1 diabetes
Xenotransplantation

ASJC Scopus subject areas

Biomedical Engineering
Bioengineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-642-12020-6-44

Cite this

@inproceedings{f202fd9d086144ef998ac11b11489e5f,

title = "Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation",

abstract = "Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.",

keywords = "Chitosan hydrogel, Encapsulation, Immunoisolation, Type 1 diabetes, Xenotransplantation",

author = "Kai-Chiang Yang and Zhi Qi and Lin, {Feng Huei} and Wu, {Chang Chin} and Shoichiro Sumi",

year = "2010",

doi = "10.1007/978-3-642-12020-6-44",

language = "English",

isbn = "9783642120190",

volume = "27",

pages = "179--181",

booktitle = "IFMBE Proceedings",

note = "3rd International Conference on the Development of Biomedical Engineering in Vietnam ; Conference date: 11-01-2010 Through 14-01-2010",

}

TY - GEN

T1 - Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation

AU - Yang, Kai-Chiang

AU - Qi, Zhi

AU - Lin, Feng Huei

AU - Wu, Chang Chin

AU - Sumi, Shoichiro

PY - 2010

Y1 - 2010

N2 - Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.

AB - Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.

KW - Chitosan hydrogel

KW - Encapsulation

KW - Immunoisolation

KW - Type 1 diabetes

KW - Xenotransplantation

UR - http://www.scopus.com/inward/record.url?scp=77952392493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952392493&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-12020-6-44

DO - 10.1007/978-3-642-12020-6-44

M3 - Conference contribution

AN - SCOPUS:77952392493

SN - 9783642120190

VL - 27

SP - 179

EP - 181

BT - IFMBE Proceedings

T2 - 3rd International Conference on the Development of Biomedical Engineering in Vietnam

Y2 - 11 January 2010 through 14 January 2010

ER -

Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation

Abstract

Other

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this