Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation

Kai-Chiang Yang, Zhi Qi, Feng Huei Lin, Chang Chin Wu, Shoichiro Sumi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages179-181
Number of pages3
Volume27
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event3rd International Conference on the Development of Biomedical Engineering in Vietnam - Ho Chi Minh City, Viet Nam
Duration: Jan 11 2010Jan 14 2010

Other

Other3rd International Conference on the Development of Biomedical Engineering in Vietnam
CountryViet Nam
CityHo Chi Minh City
Period1/11/101/14/10

Keywords

  • Chitosan hydrogel
  • Encapsulation
  • Immunoisolation
  • Type 1 diabetes
  • Xenotransplantation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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  • Cite this

    Yang, K-C., Qi, Z., Lin, F. H., Wu, C. C., & Sumi, S. (2010). Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation. In IFMBE Proceedings (Vol. 27, pp. 179-181) https://doi.org/10.1007/978-3-642-12020-6-44