Chitosan-based hydrogels prepared by UV polymerization for wound dressing

Han Yun Yao, Hong Ru Lin, Geng Pin Sue, Yiu Jiuan Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.

Original languageEnglish
Pages (from-to)155-167
Number of pages13
JournalPolymers and Polymer Composites
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

Keywords

  • 2-hydroxyethyl methacrylate
  • acrylic acid
  • Chitosan
  • epidermal growth factor
  • hydrogel
  • wound dressing

ASJC Scopus subject areas

  • Ceramics and Composites
  • Polymers and Plastics
  • Materials Chemistry

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