Chitin/PLGA blend microspheres as a biodegradable drug delivery system: A new delivery system for protein

Fwu Long Mi, Shin Shing Shyu, Yi Mei Lin, Yu Bey Wu, Chih Kang Peng, Yi Hung Tsai

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Novel chitin/PLGAs and chitin/PLA based microspheres were developed for the delivery of protein. These biodegradable microspheres were prepared by polymers blending and wet phase-inversion methods. The parameters such as selected non-solvents, temperature of water and ratio of polylactide to polyglycolide were adjusted to improve thermodynamic compatibility of individual polymer (chitin and PLGAs or chitin/PLA), which affects the hydration and degradation properties of the blend microspheres. Triphasic pattern of drug release model is observed from the release of protein from the chitin/PLGAs and chitin/PLA microspheres: the initially fast release (the first phase), the following slow release (the second phase) and the second burst release (the third phase). Formulations of the blends, which are based on the balance among the hydration rate of the chitin phase and degradation of chitin/PLA and PLGA phase, can lead to a controllable release of bovine serum albumin (BSA). In conclusion, such a chitin/PLGA 50/50 microsphere is novel and interesting, and may be used as a protein delivery system.

Original languageEnglish
Pages (from-to)5023-5036
Number of pages14
JournalBiomaterials
Volume24
Issue number27
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

Keywords

  • Biodegradable
  • Chitin
  • Drug delivery
  • Microsphere
  • Phase separation
  • PLGA 50/50

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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