Chiral liquid crystals as biosensing platforms

Mon Juan Lee, Yu Chien Sung, Yu Cheng Hsiao, Wei Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.

Original languageEnglish
Title of host publicationLiquid Crystals XX
PublisherSPIE
Volume9940
ISBN (Electronic)9781510602717
DOIs
Publication statusPublished - Jan 1 2016
Externally publishedYes
EventLiquid Crystals XX - San Diego, United States
Duration: Aug 28 2016Aug 30 2016

Conference

ConferenceLiquid Crystals XX
CountryUnited States
CitySan Diego
Period8/28/168/30/16

Fingerprint

Biosensing
Liquid Crystals
Liquid Crystal
Liquid crystals
Biomolecules
platforms
liquid crystals
Texture
Alignment
textures
Textures
alignment
bioassay
Bioassay
interruption
Surfactant
polarizers
optical microscopes
Quantitative Analysis
stems

Keywords

  • Biophotonics
  • Biosensors
  • Cholesteric liquid crystals
  • Liquid crystals
  • Transmission spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Lee, M. J., Sung, Y. C., Hsiao, Y. C., & Lee, W. (2016). Chiral liquid crystals as biosensing platforms. In Liquid Crystals XX (Vol. 9940). [99400K] SPIE. https://doi.org/10.1117/12.2236774

Chiral liquid crystals as biosensing platforms. / Lee, Mon Juan; Sung, Yu Chien; Hsiao, Yu Cheng; Lee, Wei.

Liquid Crystals XX. Vol. 9940 SPIE, 2016. 99400K.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, MJ, Sung, YC, Hsiao, YC & Lee, W 2016, Chiral liquid crystals as biosensing platforms. in Liquid Crystals XX. vol. 9940, 99400K, SPIE, Liquid Crystals XX, San Diego, United States, 8/28/16. https://doi.org/10.1117/12.2236774
Lee MJ, Sung YC, Hsiao YC, Lee W. Chiral liquid crystals as biosensing platforms. In Liquid Crystals XX. Vol. 9940. SPIE. 2016. 99400K https://doi.org/10.1117/12.2236774
Lee, Mon Juan ; Sung, Yu Chien ; Hsiao, Yu Cheng ; Lee, Wei. / Chiral liquid crystals as biosensing platforms. Liquid Crystals XX. Vol. 9940 SPIE, 2016.
@inproceedings{765a4c57012e4f8f9b0d0799b08c030a,
title = "Chiral liquid crystals as biosensing platforms",
abstract = "The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.",
keywords = "Biophotonics, Biosensors, Cholesteric liquid crystals, Liquid crystals, Transmission spectroscopy",
author = "Lee, {Mon Juan} and Sung, {Yu Chien} and Hsiao, {Yu Cheng} and Wei Lee",
year = "2016",
month = "1",
day = "1",
doi = "10.1117/12.2236774",
language = "English",
volume = "9940",
booktitle = "Liquid Crystals XX",
publisher = "SPIE",

}

TY - GEN

T1 - Chiral liquid crystals as biosensing platforms

AU - Lee, Mon Juan

AU - Sung, Yu Chien

AU - Hsiao, Yu Cheng

AU - Lee, Wei

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.

AB - The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.

KW - Biophotonics

KW - Biosensors

KW - Cholesteric liquid crystals

KW - Liquid crystals

KW - Transmission spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85006314481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006314481&partnerID=8YFLogxK

U2 - 10.1117/12.2236774

DO - 10.1117/12.2236774

M3 - Conference contribution

VL - 9940

BT - Liquid Crystals XX

PB - SPIE

ER -